Seroatlas · Human Serome Atlas

DYNLRB1

Dynein light chain roadblock-type 1

Also known as: DLRB1_HUMAN, DNCL2A, DNLC2A, ROBLD1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NP97
Gene
DYNLRB1
Ensembl
ENSG00000125971
Chromosome
20
Canonical length
96 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene is a member of the roadblock dynein light chain family. The encoded cytoplasmic protein is capable of binding intermediate chain proteins, interacts with transforming growth factor-beta, and has been implicated in the regulation of actin modulating proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 12 and 18. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

96 residues, UniProt reviewed canonical sequence.

>Q9NP97|DYNLRB1
     1  MAEVEETLKR LQSQKGVQGI IVVNTEGIPI KSTMDNPTTT QYASLMHSFI LKARSTVRDI
    61  DPQNDLTFLR IRSKKNEIMV APDKDYFLIV IQNPTE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DYNLRB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
432 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 432 nTPM
  • amygdala: 398 nTPM
  • basal ganglia: 386 nTPM
  • choroid plexus: 369 nTPM
  • hypothalamus: 368 nTPM
  • hippocampal formation: 350 nTPM

Single-cell type

  • enterocytes: 222 nCPM
  • megakaryocytes: 204 nCPM
  • goblet cells: 171 nCPM
  • epididymal clear cells: 159 nCPM
  • fallopian tube ciliated cells: 159 nCPM
  • epididymal efferent duct ciliated cells: 157 nCPM

Immune cell

  • T-reg: 255 nTPM
  • basophil: 243 nTPM
  • eosinophil: 236 nTPM
  • plasmacytoid DC: 169 nTPM
  • memory CD4 T-cell: 155 nTPM
  • memory B-cell: 155 nTPM

Brain region

  • cerebral cortex: 333 nTPM
  • white matter: 257 nTPM
  • hypothalamus: 253 nTPM
  • midbrain: 238 nTPM
  • pons: 236 nTPM
  • basal ganglia: 224 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DYNLRB1.

Disease | ImmuneIEDB

Conditions an epitope on DYNLRB1 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.02
gnomAD pLI
0.16
gnomAD missense Z
0.84
DepMap mean gene effect
-1.73
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DYNLRB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DYNLRB1 as an antibody target. Whether an autoantibody or antibody against DYNLRB1 could matter depends on whether native DYNLRB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DYNLRB1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DYNLRB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DYNLRB1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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