Tctex-1-like superfamily
IPR038586
Definition
Tctex-1 is a dynein light chain. Dynein translocates rhodopsin-bearing vesicles along microtubules and it has been shown that Tctex-1 can bind to the cytoplasmic tail of rhodopsin for retrograde or apical transport PMID:15701632. An efficient vectorial transport system must be required to deliver large numbers of newly synthesised rhodopsin molecules (~107molecules per day per photoreceptor) to the base of the outer segment of the photoreceptor, Tctex-1 may well play a role in this process. C-terminal rhodopsin mutations responsible for retinitis pigmentosa inhibit the interaction between Tctex-1 and rhodopsin, which may be the molecular basis of retinitis pigmentosa PMID:10399916. In the mouse, the chromosomal location and pattern of expression of Tctex-1 make it a candidate for involvement in male sterility PMID:2570638. This entry also includes Topoisomerase I damage affected protein 2 (TDA2) whose crystal structure revealed that it belongs to the dynein light chain family. It is part of the endocytic machinery and required for normal internalisation of native cargo in yeast PMID:28706108.
6 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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