Seroatlas · Human Serome Atlas

DNAI4

Dynein axonemal intermediate chain 4

Also known as: DIC4, DNAI4_HUMAN, FLJ23129, WDR78

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5VTH9
Gene
DNAI4
Ensembl
ENSG00000152763
Chromosome
1
Canonical length
848 aa
Protein class
Predicted intracellular proteins
Subcellular location
Flagellar centriole,Mid piece,Principal piece

OverviewNCBI Gene

Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to be involved in axonemal dynein complex assembly and cilium movement. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in axoneme; dynein axonemal particle; and motile cilium. Predicted to be part of axonemal dynein complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

848 residues, UniProt reviewed canonical sequence.

>Q5VTH9|DNAI4
     1  MTPGKHSGAS ARAANGGAWG YRDFRGGQKK GWCTTPQLVA TMPVSPAGSH KQQNFGLNNA
    61  TQPKKSISFF ATMKATSVKG YTGANQSRMA VSKTVLIPPE LKTVEKPNPN IKTTQVFDIN
   121  GTDVTPRPLY HPDPLTGTAK PSKLLTSQEG SLGSEFISSY SLYQNTINPS TLGQFTRSVL
   181  GSSTVSKSSV SASESIAEDL EEPSYKRERL TSFTDLQVIR AAPEKIVTKE DLEKNIEIIL
   241  TETETLRFFD LPTVMVSVES EEAEKVTQRN KNYEVLCRNR LGNDLYVERM MQTFNGAPKN
   301  KDVQCDKIIM EDKGIMSTAW DLYDSYNAME LVSLSVKQSV VESSSKANVL PKDQDQRLPG
   361  STTEKNSETS SLMDIENVIL AKIHEDEEDH SDAILKSDKF HQDLFFMERV LMENIFQPKL
   421  AAYRQLPVLK EPEPEEPEDV LESAKHEEVE EESKKEEEEE IHAEESTIPA NLERLWSFSC
   481  DLTKGLNVSS LAWNKTNPDL LAVGYGHFGF KEQKRGLACC WSIKNPMWPE RIYQSPYGVT
   541  AVDFSIGAPN LLAVGYHNGT IAIYNVRSNS NVPVLDSSES PQKHLGPVWQ LQWIEQDRGT
   601  TGDGKREILV SISADGRISK WVIRKGLDCY DLMRLKRTTA ASNKKGGEKE KKDEALISRQ
   661  APGMCFAFHP KDTNIYLAGT EEGHIHKCSC SYNEQYLDTY RGHKGPVYKV TWNPFCHDVF
   721  LSCSADWGVI IWQQENVKPS LSFYPATSVV YDVAWSPKSS YIFAAANENR VEIWDLHIST
   781  LDPLIVNTAN PGIKFTTILF AKQTDCLLVG DSDGQVSVYE LRNMPTVLET GRGDIMDTLL
   841  GSKSNQSA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNAI4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
33 nTPM

Expression across tissuesHPA

Tissue

  • testis: 33 nTPM
  • fallopian tube: 26 nTPM
  • choroid plexus: 19 nTPM
  • parathyroid gland: 6.5 nTPM
  • kidney: 5.9 nTPM
  • thyroid gland: 5.5 nTPM

Single-cell type

  • ependymal cells: 819 nCPM
  • respiratory ciliated cells: 666 nCPM
  • choroid plexus epithelial cells: 541 nCPM
  • fallopian tube ciliated cells: 470 nCPM
  • epididymal efferent duct ciliated cells: 376 nCPM
  • late primary spermatocytes: 303 nCPM

Immune cell

  • NK-cell: 3.8 nTPM
  • naive B-cell: 0.9 nTPM
  • naive CD4 T-cell: 0.5 nTPM
  • memory B-cell: 0.3 nTPM
  • memory CD4 T-cell: 0.3 nTPM
  • naive CD8 T-cell: 0.2 nTPM

Brain region

  • choroid plexus: 45 nTPM
  • medulla oblongata: 31 nTPM
  • midbrain: 26 nTPM
  • spinal cord: 24 nTPM
  • white matter: 21 nTPM
  • pons: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.93
gnomAD pLI
0
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DNAI4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DNAI4 as an antibody target. Whether an autoantibody or antibody against DNAI4 could matter depends on whether native DNAI4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DNAI4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DNAI4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DNAI4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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