Seroatlas · Human Serome Atlas

DYNLT3

Dynein light chain Tctex-type 3

Also known as: DYLT3_HUMAN, TCTE1L, TCTEX1L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P51808
Gene: DYNLT3
Ensembl: ENSG00000165169
Chromosome: X
Canonical length: 116 aa
Protein class: Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a member of a subclass of dynein light chains. The encoded protein homodimerizes and forms the light chain component of the cytoplasmic dynein motor protein complex. This protein may be important for binding dynein to specific cargos including the spindle checkpoint protein BUB3. This protein may also function independently of dynein as a transcriptional modulator. Pseudogenes of this gene are found on chromosomes 2 and 20.[provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

116 residues, UniProt reviewed canonical sequence.

>P51808|DYNLT3
     1  MEEYHRHCDE VGFNAEEAHN IVKECVDGVL GGEDYNHNNI NQWTASIVEQ SLTHLVKLGK
    61  AYKYIVTCAV VQKSAYGFHT ASSCFWDTTS DGTCTVRWEN RTMNCIVNVF AIAIVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DYNLT3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 60 nTPM

Expression across tissuesHPA

Tissue

esophagus: 60 nTPM
adrenal gland: 57 nTPM
hypothalamus: 53 nTPM
cerebral cortex: 53 nTPM
kidney: 47 nTPM
blood vessel: 46 nTPM

Single-cell type

esophageal apical cells: 1000 nCPM
early spermatids: 819 nCPM
late spermatids: 606 nCPM
esophageal suprabasal cells: 477 nCPM
endometrial glandular cells: 399 nCPM
late primary spermatocytes: 253 nCPM

Immune cell

MAIT T-cell: 36 nTPM
memory CD4 T-cell: 24 nTPM
memory CD8 T-cell: 23 nTPM
basophil: 21 nTPM
naive CD4 T-cell: 21 nTPM
naive CD8 T-cell: 20 nTPM

Brain region

hypothalamus: 61 nTPM
pons: 57 nTPM
medulla oblongata: 51 nTPM
midbrain: 48 nTPM
hippocampal formation: 41 nTPM
thalamus: 41 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.72
gnomAD pLI: 0.72
gnomAD missense Z: 0.12
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DYNLT3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DYNLT3 as an antibody target. Whether an autoantibody or antibody against DYNLT3 could matter depends on whether native DYNLT3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DYNLT3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DYNLT3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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