Seroatlas · Human Serome Atlas

DYNC1I1

Cytoplasmic dynein 1 intermediate chain 1

Also known as: DC1I1_HUMAN, DNCI1, DNCIC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14576
Gene
DYNC1I1
Ensembl
ENSG00000158560
Chromosome
7
Canonical length
645 aa
Protein class
Predicted intracellular proteins
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables spectrin binding activity. Involved in vesicle transport along microtubule. Located in several cellular components, including kinetochore; recycling endosome; and spindle pole. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

645 residues, UniProt reviewed canonical sequence.

>O14576|DYNC1I1
     1  MSDKSDLKAE LERKKQRLAQ IREEKKRKEE ERKKKEADMQ QKKEPVQDDS DLDRKRRETE
    61  ALLQSIGISP EPPLVQPLHF LTWDTCYFHY LVPTPMSPSS KSVSTPSEAG SQDSGDLGPL
   121  TRTLQWDTDP SVLQLQSDSE LGRRLHKLGV SKVTQVDFLP REVVSYSKET QTPLATHQSE
   181  EDEEDEEMVE SKVGQDSELE NQDKKQEVKE APPRELTEEE KQQILHSEEF LIFFDRTIRV
   241  IERALAEDSD IFFDYSGREL EEKDGDVQAG ANLSFNRQFY DEHWSKHRVV TCMDWSLQYP
   301  ELMVASYNNN EDAPHEPDGV ALVWNMKFKK TTPEYVFHCQ SSVMSVCFAR FHPNLVVGGT
   361  YSGQIVLWDN RSHRRTPVQR TPLSAAAHTH PVYCVNVVGT QNAHNLITVS TDGKMCSWSL
   421  DMLSTPQESM ELVYNKSKPV AVTGMAFPTG DVNNFVVGSE EGTVYTACRH GSKAGIGEVF
   481  EGHQGPVTGI NCHMAVGPID FSHLFVTSSF DWTVKLWTTK HNKPLYSFED NADYVYDVMW
   541  SPVHPALFAC VDGMGRLDLW NLNNDTEVPT ASVAIEGASA LNRVRWAQAG KEVAVGDSEG
   601  RIWVYDVGEL AVPHNDEWTR FARTLVEIRA NRADSEEEGT VELSA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DYNC1I1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
61 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 61 nTPM
  • cerebral cortex: 55 nTPM
  • midbrain: 42 nTPM
  • hypothalamus: 41 nTPM
  • spinal cord: 39 nTPM
  • hippocampal formation: 33 nTPM

Single-cell type

  • choroid plexus epithelial cells: 863 nCPM
  • corticotrophs: 861 nCPM
  • müller glia: 705 nCPM
  • adrenal medulla cells: 702 nCPM
  • podocytes: 687 nCPM
  • lactotrophs: 654 nCPM

Immune cell

  • neutrophil: 1.4 nTPM
  • plasmacytoid DC: 0.8 nTPM
  • NK-cell: 0.6 nTPM
  • basophil: 0.5 nTPM
  • classical monocyte: 0.3 nTPM
  • gdT-cell: 0.3 nTPM

Brain region

  • pons: 184 nTPM
  • cerebral cortex: 179 nTPM
  • midbrain: 160 nTPM
  • cerebellum: 144 nTPM
  • hypothalamus: 144 nTPM
  • hippocampal formation: 132 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.68
gnomAD pLI
0
gnomAD missense Z
2.21
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DYNC1I1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DYNC1I1 as an antibody target. Whether an autoantibody or antibody against DYNC1I1 could matter depends on whether native DYNC1I1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DYNC1I1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DYNC1I1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DYNC1I1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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