Seroatlas · Human Serome Atlas

PVR

Poliovirus receptor

Also known as: CD155, HVED, Necl-5, NECL5, PVR_HUMAN, PVS, Tage4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P15151
Gene
PVR
Ensembl
ENSG00000073008
Chromosome
19
Canonical length
417 aa
Protein class
CD markers, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Subcellular location
Nucleoplasm,Vesicles,Plasma membrane
Secretome location
Secreted - unknown location

OverviewNCBI Gene

The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Canonical amino-acid sequenceUniProt

417 residues, UniProt reviewed canonical sequence.

>P15151|PVR
     1  MARAMAAAWP LLLVALLVLS WPPPGTGDVV VQAPTQVPGF LGDSVTLPCY LQVPNMEVTH
    61  VSQLTWARHG ESGSMAVFHQ TQGPSYSESK RLEFVAARLG AELRNASLRM FGLRVEDEGN
   121  YTCLFVTFPQ GSRSVDIWLR VLAKPQNTAE VQKVQLTGEP VPMARCVSTG GRPPAQITWH
   181  SDLGGMPNTS QVPGFLSGTV TVTSLWILVP SSQVDGKNVT CKVEHESFEK PQLLTVNLTV
   241  YYPPEVSISG YDNNWYLGQN EATLTCDARS NPEPTGYNWS TTMGPLPPFA VAQGAQLLIR
   301  PVDKPINTTL ICNVTNALGA RQAELTVQVK EGPPSEHSGI SRNAIIFLVL GILVFLILLG
   361  IGIYFYWSKC SREVLWHCHL CPSSTEHASA SANGHVSYSA VSRENSSSQD PQTEGTR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PVR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
31 nTPM

Expression across tissuesHPA

Tissue

  • liver: 31 nTPM
  • heart muscle: 24 nTPM
  • lung: 17 nTPM
  • adrenal gland: 16 nTPM
  • skeletal muscle: 16 nTPM
  • pituitary gland: 15 nTPM

Single-cell type

  • cardiomyocytes: 68 nCPM
  • podocytes: 48 nCPM
  • salivary myoepithelial cells: 37 nCPM
  • tuft cells: 35 nCPM
  • epicardial cells: 30 nCPM
  • epididymal clear cells: 25 nCPM

Immune cell

  • non-classical monocyte: 5.1 nTPM
  • classical monocyte: 4.4 nTPM
  • intermediate monocyte: 4.4 nTPM
  • myeloid DC: 3.6 nTPM
  • total PBMC: 1.6 nTPM
  • neutrophil: 1.4 nTPM

Brain region

  • hypothalamus: 35 nTPM
  • pons: 29 nTPM
  • midbrain: 29 nTPM
  • medulla oblongata: 27 nTPM
  • cerebral cortex: 27 nTPM
  • cerebellum: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.3
gnomAD pLI
0
gnomAD missense Z
1
DepMap mean gene effect
-0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PVR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PVR as an antibody target. Whether an autoantibody or antibody against PVR could matter depends on whether native PVR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PVR is annotated at the cell surface, where native PVR is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PVR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PVR. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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