Dynein light chain Tctex-1-like

Definition

Tctex-1 is a dynein light chain. Dynein translocates rhodopsin-bearing vesicles along microtubules and it has been shown that Tctex-1 can bind to the cytoplasmic tail of rhodopsin for retrograde or apical transport PMID:15701632. An efficient vectorial transport system must be required to deliver large numbers of newly synthesised rhodopsin molecules (~107molecules per day per photoreceptor) to the base of the outer segment of the photoreceptor, Tctex-1 may well play a role in this process. C-terminal rhodopsin mutations responsible for retinitis pigmentosa inhibit the interaction between Tctex-1 and rhodopsin, which may be the molecular basis of retinitis pigmentosa PMID:10399916. In the mouse, the chromosomal location and pattern of expression of Tctex-1 make it a candidate for involvement in male sterility PMID:2570638.

6 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (6 proteins: gene, accession, name)

• DYNLT1
• DYNLT2
• DYNLT2B
• DYNLT3
• DYNLT4
• DYNLT5