Seroatlas · Human Serome Atlas

PNRC2

Proline-rich nuclear receptor coactivator 2

Also known as: PNRC2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NPJ4
Gene: PNRC2
Ensembl: ENSG00000189266
Chromosome: 1
Canonical length: 139 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

Involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Located in Golgi apparatus; P-body; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

139 residues, UniProt reviewed canonical sequence.

>Q9NPJ4|PNRC2
     1  MGGGERYNIP APQSRNVSKN QQQLNRQKTK EQNSQMKIVH KKKERGHGYN SSAAAWQAMQ
    61  NGGKNKNFPN NQSWNSSLSG PRLLFKSQAN QNYAGAKFSE PPSPSVLPKP PSHWVPVSFN
   121  PSDKEIMTFQ LKTLLKVQV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PNRC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 133 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 133 nTPM
lymph node: 128 nTPM
thymus: 124 nTPM
thyroid gland: 114 nTPM
tonsil: 103 nTPM
placenta: 97 nTPM

Single-cell type

epididymal basal cells: 331 nCPM
esophageal apical cells: 208 nCPM
fallopian secretory cells: 205 nCPM
parietal cells: 191 nCPM
epididymal clear cells: 186 nCPM
endometrial secretory cells: 177 nCPM

Immune cell

basophil: 233 nTPM
total PBMC: 180 nTPM
naive B-cell: 132 nTPM
T-reg: 130 nTPM
memory B-cell: 130 nTPM
eosinophil: 128 nTPM

Brain region

white matter: 60 nTPM
choroid plexus: 58 nTPM
cerebellum: 55 nTPM
medulla oblongata: 52 nTPM
pons: 52 nTPM
hypothalamus: 49 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.83
gnomAD pLI: 0.34
gnomAD missense Z: 0.19
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PNRC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PNRC2 as an antibody target. Whether an autoantibody or antibody against PNRC2 could matter depends on whether native PNRC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PNRC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PNRC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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