Seroatlas · Human Serome Atlas

NBDY

Negative regulator of P-body association

Also known as: LINC01420, NBDY_HUMAN, NoBody

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A0U1RRE5
Gene
NBDY
Ensembl
ENSG00000204272
Chromosome
X
Canonical length
68 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Involved in negative regulation of cytoplasmic mRNA processing body assembly and nuclear-transcribed mRNA catabolic process. Located in P-body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

68 residues, UniProt reviewed canonical sequence.

>A0A0U1RRE5|NBDY
     1  MGDQPCASGR STLPPGNARE AKPPKKRCLL APRWDYPEGT PNGGSTTLPS APPPASAGLK
    61  SHPPPPEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NBDY can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.75
Highest tissue expression
45 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 45 nTPM
  • choroid plexus: 44 nTPM
  • blood vessel: 43 nTPM
  • kidney: 43 nTPM
  • hypothalamus: 41 nTPM
  • pituitary gland: 39 nTPM

Single-cell type

  • extravillous trophoblasts: 400 nCPM
  • esophageal apical cells: 248 nCPM
  • megakaryocytes: 235 nCPM
  • hofbauer cells: 202 nCPM
  • urothelial cells: 199 nCPM
  • cytotrophoblasts: 199 nCPM

Immune cell

  • plasmacytoid DC: 176 nTPM
  • NK-cell: 104 nTPM
  • myeloid DC: 99 nTPM
  • T-reg: 93 nTPM
  • memory CD4 T-cell: 89 nTPM
  • naive B-cell: 87 nTPM

Brain region

  • hypothalamus: 46 nTPM
  • midbrain: 41 nTPM
  • pons: 40 nTPM
  • thalamus: 34 nTPM
  • basal ganglia: 33 nTPM
  • cerebral cortex: 31 nTPM

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Negative regulator of P-body association
  • Negative regulator of P-body association

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NBDY in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NBDY as an antibody target. Whether an autoantibody or antibody against NBDY could matter depends on whether native NBDY is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NBDY is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NBDY as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NBDY. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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