Seroatlas · Human Serome Atlas

PARK7

Parkinson disease protein 7

Also known as: DJ-1, DJ1, GATD2, PARK7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q99497
Gene
PARK7
Ensembl
ENSG00000116288
Chromosome
1
Canonical length
189 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol,Flagellar centriole,Mid piece
Quaternary structure
Homodimer

OverviewNCBI Gene

The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

189 residues, UniProt reviewed canonical sequence.

>Q99497|PARK7
     1  MASKRALVIL AKGAEEMETV IPVDVMRRAG IKVTVAGLAG KDPVQCSRDV VICPDASLED
    61  AKKEGPYDVV VLPGGNLGAQ NLSESAAVKE ILKEQENRKG LIAAICAGPT ALLAHEIGFG
   121  SKVTTHPLAK DKMMNGGHYT YSENRVEKDG LILTSRGPGT SFEFALAIVE ALNGKEVAAQ
   181  VKAPLVLKD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PARK7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
723 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 723 nTPM
  • choroid plexus: 609 nTPM
  • tongue: 506 nTPM
  • amygdala: 420 nTPM
  • cerebral cortex: 410 nTPM
  • basal ganglia: 402 nTPM

Single-cell type

  • platelets: 982 nCPM
  • decidual stromal cells: 770 nCPM
  • esophageal basal cells: 737 nCPM
  • extravillous trophoblasts: 704 nCPM
  • migrating cytotrophoblasts: 672 nCPM
  • megakaryocytes: 668 nCPM

Immune cell

  • plasmacytoid DC: 1,382 nTPM
  • total PBMC: 1,062 nTPM
  • T-reg: 877 nTPM
  • myeloid DC: 718 nTPM
  • classical monocyte: 592 nTPM
  • memory CD8 T-cell: 578 nTPM

Brain region

  • choroid plexus: 245 nTPM
  • white matter: 185 nTPM
  • hypothalamus: 181 nTPM
  • spinal cord: 175 nTPM
  • cerebral cortex: 171 nTPM
  • medulla oblongata: 171 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PARK7.

Disease | AllUniProt

Conditions PARK7 is implicated in, by any mechanism.

Disease | GeneticClinVar

17 pathogenic / likely-pathogenic of 163 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.53
gnomAD pLI
0.75
gnomAD missense Z
0.16
DepMap mean gene effect
-0.15
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PARK7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PARK7 as an antibody target. Whether an autoantibody or antibody against PARK7 could matter depends on whether native PARK7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PARK7 is annotated at the cell surface, where native PARK7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PARK7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PARK7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...