Seroatlas · Human Serome Atlas

MCRS1

Microspherule protein 1

Also known as: ICP22BP, INO80Q, MCRS1_HUMAN, MCRS2, MSP58, P78

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96EZ8
Gene
MCRS1
Ensembl
ENSG00000187778
Chromosome
12
Canonical length
462 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Enables RNA binding activity and telomerase inhibitor activity. Involved in several processes, including chromatin remodeling; positive regulation of protein localization to nucleolus; and regulation of nucleobase-containing compound metabolic process. Located in cytoplasm; nuclear body; and nucleolus. Part of Ino80 complex; MLL1 complex; and NSL complex. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

462 residues, UniProt reviewed canonical sequence.

>Q96EZ8|MCRS1
     1  MDKDSQGLLD SSLMASGTAS RSEDEESLAG QKRASSQALG TIPKRRSSSR FIKRKKFDDE
    61  LVESSLAKSS TRAKGASGVE PGRCSGSEPS SSEKKKVSKA PSTPVPPSPA PAPGLTKRVK
   121  KSKQPLQVTK DLGRWKPADD LLLINAVLQT NDLTSVHLGV KFSCRFTLRE VQERWYALLY
   181  DPVISKLACQ AMRQLHPEAI AAIQSKALFS KAEEQLLSKV GSTSQPTLET FQDLLHRHPD
   241  AFYLARTAKA LQAHWQLMKQ YYLLEDQTVQ PLPKGDQVLN FSDAEDLIDD SKLKDMRDEV
   301  LEHELMVADR RQKREIRQLE QELHKWQVLV DSITGMSSPD FDNQTLAVLR GRMVRYLMRS
   361  REITLGRATK DNQIDVDLSL EGPAWKISRK QGVIKLKNNG DFFIANEGRR PIYIDGRPVL
   421  CGSKWRLSNN SVVEIASLRF VFLINQDLIA LIRAEAAKIT PQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MCRS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
70 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 70 nTPM
  • tongue: 57 nTPM
  • skeletal muscle: 50 nTPM
  • kidney: 42 nTPM
  • thymus: 37 nTPM
  • cerebral cortex: 37 nTPM

Single-cell type

  • undifferentiated spermatogonia: 76 nCPM
  • syncytiotrophoblasts: 69 nCPM
  • extravillous trophoblasts: 67 nCPM
  • esophageal apical cells: 66 nCPM
  • esophageal suprabasal cells: 66 nCPM
  • cytotrophoblasts: 64 nCPM

Immune cell

  • basophil: 97 nTPM
  • NK-cell: 91 nTPM
  • intermediate monocyte: 83 nTPM
  • myeloid DC: 79 nTPM
  • eosinophil: 77 nTPM
  • total PBMC: 76 nTPM

Brain region

  • cerebral cortex: 41 nTPM
  • white matter: 37 nTPM
  • medulla oblongata: 34 nTPM
  • thalamus: 34 nTPM
  • basal ganglia: 34 nTPM
  • hippocampal formation: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.47
gnomAD pLI
0.17
gnomAD missense Z
2.2
DepMap mean gene effect
-0.67
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MCRS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MCRS1 as an antibody target. Whether an autoantibody or antibody against MCRS1 could matter depends on whether native MCRS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MCRS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MCRS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MCRS1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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