Seroatlas · Human Serome Atlas

ANKRD6

Ankyrin repeat domain-containing protein 6

Also known as: ANKR6_HUMAN, KIAA0957

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y2G4
Gene: ANKRD6
Ensembl: ENSG00000135299
Chromosome: 6
Canonical length: 727 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to be involved in negative regulation of canonical Wnt signaling pathway; positive regulation of JNK cascade; and protein targeting to chloroplast. Predicted to act upstream of or within positive regulation of Wnt signaling pathway, planar cell polarity pathway. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

727 residues, UniProt reviewed canonical sequence.

>Q9Y2G4|ANKRD6
     1  MSQQDAVAAL SERLLVAAYK GQTENVVQLI NKGARVAVTK HGRTPLHLAA NKGHLPVVQI
    61  LLKAGCDLDV QDDGDQTALH RATVVGNTEI IAALIHEGCA LDRQDKDGNT ALHEASWHGF
   121  SQSAKLLIKA GANVLAKNKA GNTALHLACQ NSHSQSTRVL LLAGSRADLK NNAGDTCLHV
   181  AARYNHLSII RLLLTAFCSV HEKNQAGDTA LHVAAALNHK KVAKILLEAG ADTTIVNNAG
   241  QTPLETARYH NNPEVALLLT KAPQVLRFSR GRSLRKKRER LKEERRAQSV PRDEVAQSKG
   301  SVSAGDTPSS EQAVARKEEA REEFLSASPE PRAKDDRRRK SRPKVSAFSD PTPPADQQPG
   361  HQKNLHAHNH PKKRNRHRCS SPPPPHEFRA YQLYTLYRGK DGKVMQAPIN GCRCEPLINK
   421  LENQLEATVE EIKAELGSVQ DKMNTKLGQM ENKTQHQMRV LDKLMVERLS AERTECLNRL
   481  QQHSDTEKHE GEKRQISLVD ELKTWCMLKI QNLEQKLSGD SRACRAKSTP STCESSTGVD
   541  QLVVTAGPAA ASDSSPPVVR PKEKALNSTA TQRLQQELSS SDCTGSRLRN VKVQTALLPM
   601  NEAARSDQQA GPCVNRGTQT KKSGKSGPTR HRAQQPAASS TCGQPPPATG SEQTGPHIRD
   661  TSQALELTQY FFEAVSTQME KWYERKIEEA RSQANQKAQQ DKATLKEHIK SLEEELAKLR
   721  TRVQKEN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 26 nTPM
blood vessel: 14 nTPM
cerebral cortex: 14 nTPM
ovary: 13 nTPM
fallopian tube: 8.6 nTPM
heart muscle: 7.3 nTPM

Single-cell type

medullary thymic epithelial cells: 187 nCPM
choroid plexus epithelial cells: 176 nCPM
pituitary stem cells: 174 nCPM
cone photoreceptor cells: 151 nCPM
respiratory basal cells: 141 nCPM
renal connecting tubule cells: 136 nCPM

Immune cell

eosinophil: 0.9 nTPM
intermediate monocyte: 0.7 nTPM
gdT-cell: 0.2 nTPM
NK-cell: 0.2 nTPM
classical monocyte: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM

Brain region

hypothalamus: 66 nTPM
cerebellum: 61 nTPM
basal ganglia: 44 nTPM
cerebral cortex: 40 nTPM
medulla oblongata: 35 nTPM
choroid plexus: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.91
gnomAD pLI: 0
gnomAD missense Z: 0.74
DepMap mean gene effect: -0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ANKRD6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

AXN1
AXN2
CSNK1E
AXIN2
AXIN1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD6 as an antibody target. Whether an autoantibody or antibody against ANKRD6 could matter depends on whether native ANKRD6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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