Seroatlas · Human Serome Atlas

FAM110A

Protein FAM110A

Also known as: bA371L19.3, C20orf55, F110A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BQ89
Gene: FAM110A
Ensembl: ENSG00000125898
Chromosome: 20
Canonical length: 295 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

Involved in mitotic spindle organization. Located in cytosol; microtubule cytoskeleton; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

295 residues, UniProt reviewed canonical sequence.

>Q9BQ89|FAM110A
     1  MPVHTLSPGA PSAPALPCRL RTRVPGYLLR GPADGGARKP SAVERLEADK AKYVKSLHVA
    61  NTRQEPVQPL LSKQPLFSPE TRRTVLTPSR RALPGPCRRP QLDLDILSSL IDLCDSPVSP
   121  AEASRTPGRA EGAGRPPPAT PPRPPPSTSA VRRVDVRPLP ASPARPCPSP GPAAASSPAR
   181  PPGLQRSKSD LSERFSRAAA DLERFFNFCG LDPEEARGLG VAHLARASSD IVSLAGPSAG
   241  PGSSEGGCSR RSSVTVEERA RERVPYGVSV VERNARVIKW LYGLRQARES PAAEG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM110A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 69 nTPM

Expression across tissuesHPA

Tissue

skin: 69 nTPM
esophagus: 38 nTPM
spleen: 23 nTPM
prostate: 19 nTPM
vagina: 18 nTPM
salivary gland: 18 nTPM

Single-cell type

platelets: 260 nCPM
extravillous trophoblasts: 219 nCPM
esophageal apical cells: 96 nCPM
megakaryocytes: 87 nCPM
esophageal suprabasal cells: 76 nCPM
esophageal basal cells: 60 nCPM

Immune cell

basophil: 546 nTPM
non-classical monocyte: 249 nTPM
eosinophil: 164 nTPM
intermediate monocyte: 161 nTPM
T-reg: 43 nTPM
myeloid DC: 36 nTPM

Brain region

thalamus: 13 nTPM
pons: 10 nTPM
midbrain: 10 nTPM
basal ganglia: 9.6 nTPM
medulla oblongata: 7.7 nTPM
amygdala: 7.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0.36
gnomAD missense Z: 0.64
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

mitotic spindle organization

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM110A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CSNK1E

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM110A as an antibody target. Whether an autoantibody or antibody against FAM110A could matter depends on whether native FAM110A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM110A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM110A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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