Seroatlas · Human Serome Atlas

MCC

Colorectal mutant cancer protein

Also known as: CRCM_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P23508
Gene: MCC
Ensembl: ENSG00000171444
Chromosome: 5
Canonical length: 829 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

829 residues, UniProt reviewed canonical sequence.

>P23508|MCC
     1  MNSGVAMKYG NDSSAELSEL HSAALASLKG DIVELNKRLQ QTERERDLLE KKLAKAQCEQ
    61  SHLMREHEDV QERTTLRYEE RITELHSVIA ELNKKIDRLQ GTTIREEDEY SELRSELSQS
   121  QHEVNEDSRS MDQDQTSVSI PENQSTMVTA DMDNCSDLNS ELQRVLTGLE NVVCGRKKSS
   181  CSLSVAEVDK HIEQLTTASE HCDLAIKTVE EIEGVLGRDL YPNLAEERSR WEKELAGLRE
   241  ENESLTAMLC SKEEELNRTK ATMNAIREER DRLRRRVREL QTRLQSVQAT GPSSPGRLTS
   301  TNRPINPSTG ELSTSSSSND IPIAKIAERV KLSKTRSESS SSDRPVLGSE ISSIGVSSSV
   361  AEHLAHSLQD CSNIQEIFQT LYSHGSAISE SKIREFEVET ERLNSRIEHL KSQNDLLTIT
   421  LEECKSNAER MSMLVGKYES NATALRLALQ YSEQCIEAYE LLLALAESEQ SLILGQFRAA
   481  GVGSSPGDQS GDENITQMLK RAHDCRKTAE NAAKALLMKL DGSCGGAFAV AGCSVQPWES
   541  LSSNSHTSTT SSTASSCDTE FTKEDEQRLK DYIQQLKNDR AAVKLTMLEL ESIHIDPLSY
   601  DVKPRGDSQR LDLENAVLMQ ELMAMKEEMA ELKAQLYLLE KEKKALELKL STREAQEQAY
   661  LVHIEHLKSE VEEQKEQRMR SLSSTSSGSK DKPGKECADA ASPALSLAEL RTTCSENELA
   721  AEFTNAIRRE KKLKARVQEL VSALERLTKS SEIRHQQSAE FVNDLKRANS NLVAAYEKAK
   781  KKHQNKLKKL ESQMMAMVER HETQVRMLKQ RIALLEEENS RPHTNETSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MCC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

ovary: 55 nTPM
parathyroid gland: 31 nTPM
skin: 20 nTPM
liver: 18 nTPM
cervix: 14 nTPM
retina: 14 nTPM

Single-cell type

bergmann glia: 896 nCPM
lacrimal acinar cells: 763 nCPM
retinal bipolar cells: 710 nCPM
basal prostatic cells: 514 nCPM
salivary basal cells: 464 nCPM
respiratory basal cells: 423 nCPM

Immune cell

plasmacytoid DC: 2.7 nTPM
T-reg: 0.7 nTPM
MAIT T-cell: 0.6 nTPM
neutrophil: 0.5 nTPM
gdT-cell: 0.2 nTPM
memory CD4 T-cell: 0.2 nTPM

Brain region

midbrain: 61 nTPM
thalamus: 48 nTPM
medulla oblongata: 40 nTPM
hypothalamus: 39 nTPM
cerebellum: 33 nTPM
spinal cord: 32 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MCC.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 225 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Carcinoma of colon

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.84
gnomAD pLI: 0
gnomAD missense Z: -0.88
DepMap mean gene effect: 0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

signaling receptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MCC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MCC as an antibody target. Whether an autoantibody or antibody against MCC could matter depends on whether native MCC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MCC is annotated at the cell surface, where native MCC is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MCC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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