SH2D3C

Protein identityUniProt · HPA

UniProt accession

Q8N5H7

Gene

SH2D3C

Ensembl

ENSG00000095370

Chromosome

9

Canonical length

860 aa

Protein class

Predicted intracellular proteins

Subcellular location

Cytosol

OverviewNCBI Gene

This gene encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. The encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Canonical amino-acid sequenceUniProt

860 residues, UniProt reviewed canonical sequence.

>Q8N5H7|SH2D3C
     1  MTEGTKKTSK KFKFFKFKGF GSLSNLPRSF TLRRSSASIS RQSHLEPDTF EATQDDMVTV
    61  PKSPPAYARS SDMYSHMGTM PRPSIKKAQN SQAARQAQEA GPKPNLVPGG VPDPPGLEAA
   121  KEVMVKATGP LEDTPAMEPN PSAVEVDPIR KPEVPTGDVE EERPPRDVHS ERAAGEPEAG
   181  SDYVKFSKEK YILDSSPEKL HKELEEELKL SSTDLRSHAW YHGRIPREVS ETLVQRNGDF
   241  LIRDSLTSLG DYVLTCRWRN QALHFKINKV VVKAGESYTH IQYLFEQESF DHVPALVRYH
   301  VGSRKAVSEQ SGAIIYCPVN RTFPLRYLEA SYGLGQGSSK PASPVSPSGP KGSHMKRRSV
   361  TMTDGLTADK VTRSDGCPTS TSLPRPRDSI RSCALSMDQI PDLHSPMSPI SESPSSPAYS
   421  TVTRVHAAPA APSATALPAS PVARRSSEPQ LCPGSAPKTH GESDKGPHTS PSHTLGKASP
   481  SPSLSSYSDP DSGHYCQLQP PVRGSREWAA TETSSQQARS YGERLKELSE NGAPEGDWGK
   541  TFTVPIVEVT SSFNPATFQS LLIPRDNRPL EVGLLRKVKE LLAEVDARTL ARHVTKVDCL
   601  VARILGVTKE MQTLMGVRWG MELLTLPHGR QLRLDLLERF HTMSIMLAVD ILGCTGSAEE
   661  RAALLHKTIQ LAAELRGTMG NMFSFAAVMG ALDMAQISRL EQTWVTLRQR HTEGAILYEK
   721  KLKPFLKSLN EGKEGPPLSN TTFPHVLPLI TLLECDSAPP EGPEPWGSTE HGVEVVLAHL
   781  EAARTVAHHG GLYHTNAEVK LQGFQARPEL LEVFSTEFQM RLLWGSQGAS SSQARRYEKF
   841  DKVLTALSHK LEPAVRSSEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SH2D3C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.48

Highest tissue expression

49 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.59

gnomAD pLI

0

gnomAD missense Z

1.95

DepMap mean gene effect

0.01

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• JNK cascade
• small GTPase-mediated signal transduction

Molecular functions

• guanyl-nucleotide exchange factor activity
• phosphotyrosine residue binding

Cellular components

• axon
• cytosol
• ruffle membrane

Protein domainsUniProt · Pfam · InterPro

• SH2 domain
• Ras guanine-nucleotide exchange factors catalytic domain
• Ras guanine nucleotide exchange factor domain superfamily
• SH2 domain superfamily
• Ras guanine-nucleotide exchange factor, catalytic domain superfamily
• SHEP1/BCAR3/NSP1, SH2 domain
• Adapter protein with SH2 and Ras-GEF domains
• SH2 domain
• RasGEF domain

KeywordsUniProt

• Cell membrane
• Cell projection
• Cytoplasm
• Membrane
• Phosphoprotein
• SH2 domain

InteractionsUniProt · HPA

Protein binding partners of SH2D3C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• EPHB2
• IGF1
• PTK2B
• BCAR1
• CRK
• EGFR