Seroatlas · Human Serome Atlas

CD247

T-cell surface glycoprotein CD3 zeta chain

Also known as: CD3-ZETA, CD3H, CD3Q, CD3Z, CD3Z_HUMAN, CD3ZETA, TCRZ

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P20963
Gene
CD247
Ensembl
ENSG00000198821
Chromosome
1
Canonical length
164 aa
Protein class
CD markers, Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

164 residues, UniProt reviewed canonical sequence.

>P20963|CD247
     1  MKWKALFTAA ILQAQLPITE AQSFGLLDPK LCYLLDGILF IYGVILTALF LRVKFSRSAD
    61  APAYQQGQNQ LYNELNLGRR EEYDVLDKRR GRDPEMGGKP QRRKNPQEGL YNELQKDKMA
   121  EAYSEIGMKG ERRRGKGHDG LYQGLSTATK DTYDALHMQA LPPR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD247 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.64
Highest tissue expression
150 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 150 nTPM
  • lymph node: 48 nTPM
  • spleen: 39 nTPM
  • bone marrow: 38 nTPM
  • tonsil: 30 nTPM
  • appendix: 22 nTPM

Single-cell type

  • nk-cells: 2,151 nCPM
  • t-cells: 627 nCPM
  • innate lymphoid cells: 191 nCPM
  • thymocytes: 42 nCPM
  • epididymal principal cells: 38 nCPM
  • cardiomyocytes: 34 nCPM

Immune cell

  • gdT-cell: 337 nTPM
  • T-reg: 243 nTPM
  • naive CD4 T-cell: 228 nTPM
  • total PBMC: 218 nTPM
  • NK-cell: 213 nTPM
  • memory CD8 T-cell: 206 nTPM

Brain region

  • cerebral cortex: 2.6 nTPM
  • thalamus: 2.4 nTPM
  • basal ganglia: 2.1 nTPM
  • white matter: 2.1 nTPM
  • amygdala: 1.9 nTPM
  • cerebellum: 1.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CD247.

Disease | AllUniProt

Conditions CD247 is implicated in, by any mechanism.

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 203 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.82
gnomAD pLI
0.02
gnomAD missense Z
-0.31
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CD247 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CD247 as an antibody target. Whether an autoantibody or antibody against CD247 could matter depends on whether native CD247 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CD247 is annotated at the cell surface, where native CD247 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CD247 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CD247. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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