Seroatlas · Human Serome Atlas

DOCK5

Dedicator of cytokinesis protein 5

Also known as: DOCK5_HUMAN, FLJ21034

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H7D0
Gene: DOCK5
Ensembl: ENSG00000147459
Chromosome: 8
Canonical length: 1870 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family act as guanine nucleotide exchange factors for small Rho family G proteins. The protein encoded by this gene is thought to associate with adaptors CRK and CRKL, and function in regulation of intestinal epithelial cell spreading and migration on collagen IV. Similar proteins in mouse and zebrafish also function in myoblast fusion. [provided by RefSeq, Oct 2016]

Canonical amino-acid sequenceUniProt

1870 residues, UniProt reviewed canonical sequence.

>Q9H7D0|DOCK5
     1  MARWIPTKRQ KYGVAIYNYN ASQDVELSLQ IGDTVHILEM YEGWYRGYTL QNKSKKGIFP
    61  ETYIHLKEAT VEDLGQHETV IPGELPLVQE LTSTLREWAV IWRKLYVNNK LTLFRQLQQM
   121  TYSLIEWRSQ ILSGTLPKDE LAELKKKVTA KIDHGNRMLG LDLVVRDDNG NILDPDETST
   181  IALFKAHEVA SKRIEEKIQE EKSILQNLDL RGQSIFSTIH TYGLYVNFKN FVCNIGEDAE
   241  LFMALYDPDQ STFISENYLI RWGSNGMPKE IEKLNNLQAV FTDLSSMDLI RPRVSLVCQI
   301  VRVGHMELKE GKKHTCGLRR PFGVAVMDIT DIIHGKVDDE EKQHFIPFQQ IAMETYIRQR
   361  QLIMSPLITS HVIGENEPLT SVLNKVIAAK EVNHKGQGLW VSLKLLPGDL TQVQKNFSHL
   421  VDRSTAIARK MGFPEIILPG DVRNDIYVTL IHGEFDKGKK KTPKNVEVTM SVHDEEGKLL
   481  EKAIHPGAGY EGISEYKSVV YYQVKQPCWY ETVKVSIAIE EVTRCHIRFT FRHRSSQETR
   541  DKSERAFGVA FVKLMNPDGT TLQDGRHDLV VYKGDNKKME DAKFYLTLPG TKMEMEEKEL
   601  QASKNLVTFT PSKDSTKDSF QIATLICSTK LTQNVDLLGL LNWRSNSQNI KHNLKKLMEV
   661  DGGEIVKFLQ DTLDALFNIM MEMSDSETYD FLVFDALVFI ISLIGDIKFQ HFNPVLETYI
   721  YKHFSATLAY VKLSKVLNFY VANADDSSKT ELLFAALKAL KYLFRFIIQS RVLYLRFYGQ
   781  SKDGDEFNNS IRQLFLAFNM LMDRPLEEAV KIKGAALKYL PSIINDVKLV FDPVELSVLF
   841  CKFIQSIPDN QLVRQKLNCM TKIVESTLFR QSECREVLLP LLTDQLSGQL DDNSNKPDHE
   901  ASSQLLSNIL EVLDRKDVGA TAVHIQLIME RLLRRINRTV IGMNRQSPHI GSFVACMIAL
   961  LQQMDDSHYS HYISTFKTRQ DIIDFLMETF IMFKDLIGKN VYAKDWMVMN MTQNRVFLRA
  1021  INQFAEVLTR FFMDQASFEL QLWNNYFHLA VAFLTHESLQ LETFSQAKRN KIVKKYGDMR
  1081  KEIGFRIRDM WYNLGPHKIK FIPSMVGPIL EVTLTPEVEL RKATIPIFFD MMQCEFNFSG
  1141  NGNFHMFENE LITKLDQEVE GGRGDEQYKV LLEKLLLEHC RKHKYLSSSG EVFALLVSSL
  1201  LENLLDYRTI IMQDESKENR MSCTVNVLNF YKEKKREDIY IRYLYKLRDL HRDCENYTEA
  1261  AYTLLLHAEL LQWSDKPCVP HLLQKDSYYV YTQQELKEKL YQEIISYFDK GKMWEKAIKL
  1321  SKELAETYES KVFDYEGLGN LLKKRASFYE NIIKAMRPQP EYFAVGYYGQ GFPSFLRNKI
  1381  FIYRGKEYER REDFSLRLLT QFPNAEKMTS TTPPGEDIKS SPKQYMQCFT VKPVMSLPPS
  1441  YKDKPVPEQI LNYYRANEVQ QFRYSRPFRK GEKDPDNEFA TMWIERTTYT TAYTFPGILK
  1501  WFEVKQISTE EISPLENAIE TMELTNERIS NCVQQHAWDR SLSVHPLSML LSGIVDPAVM
  1561  GGFSNYEKAF FTEKYLQEHP EDQEKVELLK RLIALQMPLL TEGIRIHGEK LTEQLKPLHE
  1621  RLSSCFRELK EKVEKHYGVI TLPPNLTERK QSRTGSIVLP YIMSSTLRRL SITSVTSSVV
  1681  STSSNSSDNA PSRPGSDGSI LEPLLERRAS SGARVEDLSL REENSENRIS KFKRKDWSLS
  1741  KSQVIAEKAP EPDLMSPTRK AQRPKSLQLM DNRLSPFHGS SPPQSTPLSP PPLTPKATRT
  1801  LSSPSLQTDG IAATPVPPPP PPKSKPYEGS QRNSTELAPP LPVRREAKAP PPPPPKARKS
  1861  GIPTSEPGSQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DOCK5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

spleen: 18 nTPM
bone marrow: 16 nTPM
blood vessel: 15 nTPM
liver: 14 nTPM
thyroid gland: 14 nTPM
spinal cord: 13 nTPM

Single-cell type

neutrophils: 3,295 nCPM
podocytes: 2,268 nCPM
oligodendrocytes: 1,107 nCPM
thyrotrophs: 748 nCPM
lymphatic endothelial cells: 640 nCPM
thymocytes: 616 nCPM

Immune cell

neutrophil: 31 nTPM
basophil: 15 nTPM
non-classical monocyte: 6.8 nTPM
intermediate monocyte: 5.5 nTPM
eosinophil: 3.8 nTPM
classical monocyte: 2.5 nTPM

Brain region

white matter: 199 nTPM
basal ganglia: 143 nTPM
medulla oblongata: 119 nTPM
pons: 119 nTPM
thalamus: 111 nTPM
midbrain: 110 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.44
gnomAD pLI: 0
gnomAD missense Z: 1.05
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DOCK5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DOCK5 as an antibody target. Whether an autoantibody or antibody against DOCK5 could matter depends on whether native DOCK5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DOCK5 is annotated at the cell surface, where native DOCK5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label DOCK5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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