Seroatlas · Human Serome Atlas

GAREM1

GRB2-associated and regulator of MAPK protein 1

Also known as: C18orf11, FAM59A, FLJ21610, GARE1_HUMAN, GAREM

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H706
Gene: GAREM1
Ensembl: ENSG00000141441
Chromosome: 18
Canonical length: 876 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes an adaptor protein which functions in the epidermal growth factor (EGF) receptor-mediated signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

876 residues, UniProt reviewed canonical sequence.

>Q9H706|GAREM1
     1  MDPAPSLGCS LKDVKWSSVA VPLDLLVSTY RLPQIARLDN GECVEGLREN DYLLIHSCRQ
    61  WTTITAHSLE EGHYVIGPKI EIPVHYAGQF KLLEQDRDIK EPVQYFNSVE EVAKAFPERV
   121  YVMEDITFNV KVASGECNED TEVYNITLCT GDELTLMGQA EILYAKTFKE KSRLNTIFKK
   181  IGKLNSISKL GKGKMPCLIC MNHRTNESIS LPFQCKGRFS TRSPLELQMQ EGEHTIRNIV
   241  EKTRLPVNVT VPSPPPRNPY DLHFIREGHR YKFVNIQTKT VVVCCVLRNN KILPMHFPLH
   301  LTVPKFSLPE HLVKGESWPE TLVHHWLGIC QEQFDIDEYS RAVRDVKTDW NEECKSPKKG
   361  RCSGHNHVPN SLSYARDELT QSFHRLSVCV YGNNLHGNSE VNLHGCRDLG GDWAPFPHDI
   421  LPYQDSGDSG SDYLFPEASE ESAGIPGKSE LPYEELWLEE GKPSHQPLTR SLSEKNRCDQ
   481  FRGSVRSKCA TSPLPIPGTL GAAVKSSDTA LPPPPVPPKS EAVREECRLL NAPPVPPRSA
   541  KPLSTSPSIP PRTVKPARQQ TRSPSPTLSY YSSGLHNISV TKTDTNPSES TPVSCYPCNR
   601  VKTDSVDLKS PFGSPSAEAV SSRLSWPNHY SGASESQTRS DFLLDPSRSY SYPRQKTPGT
   661  PKRNCPAPFD FDGCELLASP TSPVTAEFSS SVSGCPKSAS YSLESTDVKS LAAGVTKQST
   721  SCPALPPRAP KLVEEKVASE TSPLPLKIDG AEEDPKSGSP DLSEDQYFVK KGMQDIFSAS
   781  YPFSSPLHLQ LAPRSCGDGS PWQPPADLSG LSIEEVSKSL RFIGLSEDVI SFFVTEKIDG
   841  NLLVQLTEEI LSEDFKLSKL QVKKIMQFIN GWRPKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GAREM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

pancreas: 28 nTPM
kidney: 11 nTPM
skin: 8.2 nTPM
stomach: 8 nTPM
salivary gland: 7.4 nTPM
bone marrow: 6.8 nTPM

Single-cell type

pituicytes/fscs: 1,824 nCPM
urothelial cells: 1,483 nCPM
endometrial glandular cells: 868 nCPM
renal connecting tubule cells: 663 nCPM
pancreatic acinar cells: 543 nCPM
bergmann glia: 495 nCPM

Immune cell

plasmacytoid DC: 1.9 nTPM
NK-cell: 1.1 nTPM
neutrophil: 1 nTPM
naive B-cell: 0.6 nTPM
naive CD8 T-cell: 0.5 nTPM
classical monocyte: 0.3 nTPM

Brain region

white matter: 31 nTPM
medulla oblongata: 29 nTPM
hippocampal formation: 28 nTPM
spinal cord: 24 nTPM
pons: 24 nTPM
cerebellum: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.44
gnomAD pLI: 0.2
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

proline-rich region binding

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GAREM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GAREM1 as an antibody target. Whether an autoantibody or antibody against GAREM1 could matter depends on whether native GAREM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GAREM1 is annotated at the cell surface, where native GAREM1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GAREM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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