GTSE1

Protein identityUniProt · HPA

UniProt accession

Q9NYZ3

Gene

GTSE1

Ensembl

ENSG00000075218

Chromosome

22

Canonical length

739 aa

Protein class

Plasma proteins, Predicted intracellular proteins

Subcellular location

Plasma membrane,Centrosome

OverviewNCBI Gene

The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

739 residues, UniProt reviewed canonical sequence.

>Q9NYZ3|GTSE1
     1  MEGGGGRDEP SACRAGDVNM DDPKKEDILL LADEKFDFDL SLSSSSANED DEVFFGPFGH
    61  KERCIAASLE LNNPVPEQPP LPTSESPFAW SPLAGEKFVE VYKEAHLLAL HIESSSRNQA
   121  AQAAKPEDPR SQGVERFIQE SKLKINLFEK EKEMKKSPTS LKRETYYLSD SPLLGPPVGE
   181  PRLLASSPAL PSSGAQARLT RAPGPPHSAH ALPRESCTAH AASQAATQRK PGTKLLLPRA
   241  ASVRGRSIPG AAEKPKKEIP ASPSRTKIPA EKESHRDVLP DKPAPGAVNV PAAGSHLGQG
   301  KRAIPVPNKL GLKKTLLKAP GSTSNLARKS SSGPVWSGAS SACTSPAVGK AKSSEFASIP
   361  ANSSRPLSNI SKSGRMGPAM LRPALPAGPV GASSWQAKRV DVSELAAEQL TAPPSASPTQ
   421  PQTPEGGGQW LNSSCAWSES SQLNKTRSIR RRDSCLNSKT KVMPTPTNQF KIPKFSIGDS
   481  PDSSTPKLSR AQRPQSCTSV GRVTVHSTPV RRSSGPAPQS LLSAWRVSAL PTPASRRCSG
   541  LPPMTPKTMP RAVGSPLCVP ARRRSSEPRK NSAMRTEPTR ESNRKTDSRL VDVSPDRGSP
   601  PSRVPQALNF SPEESDSTFS KSTATEVARE EAKPGGDAAP SEALLVDIKL EPLAVTPDAA
   661  SQPLIDLPLI DFCDTPEAHV AVGSESRPLI DLMTNTPDMN KNVAKPSPVV GQLIDLSSPL
   721  IQLSPEADKE NVDSPLLKF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GTSE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.72

Highest tissue expression

18 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.74

gnomAD pLI

0

gnomAD missense Z

0.06

DepMap mean gene effect

-0.25

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• DNA damage response, signal transduction by p53 class mediator
• microtubule-based process

Molecular functions

• microtubule binding

Cellular components

• cytoplasmic microtubule
• cytosol
• membrane
• microtubule cytoskeleton
• nucleoplasm

Protein domainsUniProt · Pfam · InterPro

• Proline/serine-rich coiled-coil protein 1/G2 and S phase-expressed protein 1
• G2 and S phase-expressed protein 1, N-terminal
• G-2 and S-phase expressed 1

KeywordsUniProt

• Cytoplasm
• Cytoskeleton
• Microtubule
• Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of GTSE1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CLTA
• MAPRE1