Seroatlas · Human Serome Atlas

EPN2

Epsin-2

Also known as: EHB21, EPN2_HUMAN, KIAA1065

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95208
Gene: EPN2
Ensembl: ENSG00000072134
Chromosome: 17
Canonical length: 641 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

This gene encodes a protein which interacts with clathrin and adaptor-related protein complex 2, alpha 1 subunit. The protein is found in a brain-derived clathrin-coated vesicle fraction and localizes to the peri-Golgi region and the cell periphery. The protein is thought to be involved in clathrin-mediated endocytosis. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

641 residues, UniProt reviewed canonical sequence.

>O95208|EPN2
     1  MTTSSIRRQM KNIVNNYSEA EIKVREATSN DPWGPSSSLM TEIADLTYNV VAFSEIMSMV
    61  WKRLNDHGKN WRHVYKALTL LDYLIKTGSE RVAQQCRENI FAIQTLKDFQ YIDRDGKDQG
   121  INVREKSKQL VALLKDEERL KAERAQALKT KERMAQVATG MGSNQITFGR GSSQPNLSTS
   181  HSEQEYGKAG GSPASYHGSP EASLCPQHRT GAPLGQSEEL QPLSQRHPFL PHLGLASRPN
   241  GDWSQPCLTC DRAARATSPR VSSELEQARP QTSGEEELQL QLALAMSREV AEQEERLRRG
   301  DDLRLQMALE ESRRDTVKIP KKKEHGSLPQ QTTLLDLMDA LPSSGPAAQK AEPWGPSAST
   361  NQTNPWGGPA APASTSDPWP SFGTKPAASI DPWGVPTGAT VQSVPKNSDP WAASQQPASS
   421  AGKRASDAWG AVSTTKPVSV SGSFELFSNL NGTIKDDFSE FDNLRTSKKT AESVTSLPSQ
   481  NNGTTSPDPF ESQPLTVASS KPSSARKTPE SFLGPNAALV NLDSLVTRPA PPAQSLNPFL
   541  APGAPATSAP VNPFQVNQPQ PLTLNQLRGS PVLGTSTSFG PGPGVESMAV ASMTSAAPQP
   601  ALGATGSSLT PLGPAMMNMV GSVGIPPSAA QATGTTNPFL L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EPN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 63 nTPM

Expression across tissuesHPA

Tissue

hippocampal formation: 63 nTPM
amygdala: 61 nTPM
spinal cord: 52 nTPM
cerebral cortex: 51 nTPM
skin: 46 nTPM
midbrain: 45 nTPM

Single-cell type

oligodendrocyte progenitor cells: 1,696 nCPM
oligodendrocytes: 432 nCPM
esophageal apical cells: 296 nCPM
suprabasal keratinocytes: 264 nCPM
esophageal suprabasal cells: 257 nCPM
fibro-adipogenic progenitors: 235 nCPM

Immune cell

eosinophil: 28 nTPM
basophil: 13 nTPM
neutrophil: 8.6 nTPM
naive B-cell: 3.3 nTPM
memory B-cell: 2.9 nTPM
gdT-cell: 1.4 nTPM

Brain region

white matter: 194 nTPM
cerebral cortex: 149 nTPM
basal ganglia: 144 nTPM
midbrain: 144 nTPM
thalamus: 143 nTPM
hippocampal formation: 142 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.4
gnomAD pLI: 0.75
gnomAD missense Z: 1.39
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EPN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EPN2 as an antibody target. Whether an autoantibody or antibody against EPN2 could matter depends on whether native EPN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EPN2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EPN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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