Seroatlas · Human Serome Atlas

PAAT

ATPase PAAT

Also known as: C10orf88, Em:AC073585.5, FLJ13490, PAAT_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H8K7
Gene: PAAT
Ensembl: ENSG00000119965
Chromosome: 10
Canonical length: 445 aa
Protein class: Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables ATP hydrolysis activity. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

445 residues, UniProt reviewed canonical sequence.

>Q9H8K7|PAAT
     1  METRTEDGGL TRRPTLASSW DVAGGALTHS LLLTRAGLGP GDFDWEELLA PPAPGQDLVI
    61  LKRNHNNKDE NPCFLYLRCG PDGGEEIASI GILSSARNME VYLGEEYCGT SRGKNVCTVL
   121  DDSEHEKIIL YKKNLKLESS THACKIKLLS FGERQCVFIS KVVVHMRSVF ANSSTSSPAL
   181  GSRIDLDKVQ TIMESMGSKL SPGAQQLMDM VRCQQRNCIP IGEQLQSVLG NSGYKHMIGL
   241  QSSSTLGTLN KSSSTPFPFR TGLTSGNVTE NLQTYIDKST QLPGGENSTK LDECKVMPQN
   301  HSFLENDLKN AMASFLPKKV SDNSNIPNSE LLPFLQNLCS QVNHLHVGNK TECQENITKH
   361  GERILGVGME EQSICSYLEK ILSKNMELME KKLMDYIDQR IHELQEHIDD KIALLLDLLQ
   421  NPNSPPTGIP LRHYDSGERL SNGER

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PAAT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

testis: 10 nTPM
retina: 6.1 nTPM
cerebellum: 5.8 nTPM
lymph node: 5.5 nTPM
hypothalamus: 4.9 nTPM
cerebral cortex: 4.8 nTPM

Single-cell type

late primary spermatocytes: 162 nCPM
early spermatids: 114 nCPM
early primary spermatocytes: 57 nCPM
late spermatids: 52 nCPM
thyrotrophs: 24 nCPM
corticotrophs: 23 nCPM

Immune cell

T-reg: 5.3 nTPM
NK-cell: 3.9 nTPM
memory CD4 T-cell: 3.6 nTPM
memory CD8 T-cell: 3.6 nTPM
naive CD4 T-cell: 3.5 nTPM
eosinophil: 3.4 nTPM

Brain region

hypothalamus: 6.2 nTPM
cerebral cortex: 6 nTPM
white matter: 5.9 nTPM
pons: 5.8 nTPM
thalamus: 5.7 nTPM
midbrain: 5.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.72
gnomAD pLI: 0.01
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

ATPase PAAT-like
ATPase PAAT-like

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PAAT in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PAAT as an antibody target. Whether an autoantibody or antibody against PAAT could matter depends on whether native PAAT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PAAT is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PAAT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...