Seroatlas · Human Serome Atlas

BIRC7

Baculoviral IAP repeat-containing protein 7

Also known as: BIRC7_HUMAN, KIAP, ML-IAP, mliap, RNF50

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96CA5
Gene
BIRC7
Ensembl
ENSG00000101197
Chromosome
20
Canonical length
298 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Centrosome,Cytosol

OverviewNCBI Gene

This gene encodes a member of the inhibitor of apoptosis protein (IAP) family, and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Elevated levels of the encoded protein may be associated with cancer progression and play a role in chemotherapy sensitivity. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

298 residues, UniProt reviewed canonical sequence.

>Q96CA5|BIRC7
     1  MGPKDSAKCL HRGPQPSHWA AGDGPTQERC GPRSLGSPVL GLDTCRAWDH VDGQILGQLR
    61  PLTEEEEEEG AGATLSRGPA FPGMGSEELR LASFYDWPLT AEVPPELLAA AGFFHTGHQD
   121  KVRCFFCYGG LQSWKRGDDP WTEHAKWFPS CQFLLRSKGR DFVHSVQETH SQLLGSWDPW
   181  EEPEDAAPVA PSVPASGYPE LPTPRREVQS ESAQEPGGVS PAEAQRAWWV LEPPGARDVE
   241  AQLRRLQEER TCKVCLDRAV SIVFVPCGHL VCAECAPGLQ LCPICRAPVR SRVRTFLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BIRC7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
6.1 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 6.1 nTPM
  • skin: 2.2 nTPM
  • spinal cord: 1.6 nTPM
  • cervix: 1.3 nTPM
  • lymph node: 1.2 nTPM
  • lung: 1.1 nTPM

Single-cell type

  • hofbauer cells: 173 nCPM
  • migrating cytotrophoblasts: 89 nCPM
  • epididymal efferent duct absorptive cells: 56 nCPM
  • müller glia: 53 nCPM
  • melanocytes: 37 nCPM
  • extravillous trophoblasts: 24 nCPM

Immune cell

  • naive CD8 T-cell: 0.3 nTPM
  • naive CD4 T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • white matter: 3.4 nTPM
  • thalamus: 2.8 nTPM
  • medulla oblongata: 2.6 nTPM
  • hypothalamus: 2.3 nTPM
  • amygdala: 1.8 nTPM
  • hippocampal formation: 1.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about BIRC7.

Disease | ImmuneIEDB

Conditions an epitope on BIRC7 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.34
gnomAD pLI
0
gnomAD missense Z
-0.01
DepMap mean gene effect
0.13
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BIRC7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BIRC7 as an antibody target. Whether an autoantibody or antibody against BIRC7 could matter depends on whether native BIRC7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BIRC7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BIRC7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BIRC7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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