Seroatlas · Human Serome Atlas

NTAQ1

Protein N-terminal glutamine amidohydrolase

Also known as: C8orf32, FLJ10204, NTAQ1_HUMAN, WDYHV1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96HA8
Gene
NTAQ1
Ensembl
ENSG00000156795
Chromosome
8
Canonical length
205 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles

OverviewNCBI Gene

Predicted to enable protein-N-terminal glutamine amidohydrolase activity. Predicted to be involved in protein modification process. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

205 residues, UniProt reviewed canonical sequence.

>Q96HA8|NTAQ1
     1  MEGNGPAAVH YQPASPPRDA CVYSSCYCEE NIWKLCEYIK NHDQYPLEEC YAVFISNERK
    61  MIPIWKQQAR PGDGPVIWDY HVVLLHVSSG GQNFIYDLDT VLPFPCLFDT YVEDAFKSDD
   121  DIHPQFRRKF RVIRADSYLK NFASDRSHMK DSSGNWREPP PPYPCIETGD SKMNLNDFIS
   181  MDPKVGWGAV YTLSEFTHRF GSKNC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NTAQ1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 20 nTPM
  • choroid plexus: 20 nTPM
  • hypothalamus: 20 nTPM
  • heart muscle: 19 nTPM
  • ovary: 19 nTPM
  • spinal cord: 18 nTPM

Single-cell type

  • differentiating spermatogonia: 56 nCPM
  • retinal horizontal cells: 40 nCPM
  • sertoli cells: 39 nCPM
  • undifferentiated spermatogonia: 39 nCPM
  • oocytes: 37 nCPM
  • gastric progenitor cells: 36 nCPM

Immune cell

  • basophil: 16 nTPM
  • NK-cell: 16 nTPM
  • T-reg: 11 nTPM
  • myeloid DC: 9.1 nTPM
  • intermediate monocyte: 8.7 nTPM
  • memory CD8 T-cell: 7.7 nTPM

Brain region

  • thalamus: 24 nTPM
  • hypothalamus: 21 nTPM
  • midbrain: 19 nTPM
  • white matter: 18 nTPM
  • pons: 18 nTPM
  • medulla oblongata: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.35
gnomAD pLI
0
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Protein N-terminal glutamine amidohydrolase, alpha beta roll
  • Protein N-terminal glutamine amidohydrolase, alpha beta roll superfamily
  • Protein N-terminal glutamine amidohydrolase
  • N-terminal glutamine amidase

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NTAQ1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NTAQ1 as an antibody target. Whether an autoantibody or antibody against NTAQ1 could matter depends on whether native NTAQ1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NTAQ1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NTAQ1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NTAQ1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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