Seroatlas · Human Serome Atlas

RIPK2

Receptor-interacting serine/threonine-protein kinase 2

Also known as: CARD3, CARDIAK, RICK, RIP2, RIPK2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43353
Gene
RIPK2
Ensembl
ENSG00000104312
Chromosome
8
Canonical length
540 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Cytosol
Quaternary structure
Homooligomer

OverviewNCBI Gene

This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

540 residues, UniProt reviewed canonical sequence.

>O43353|RIPK2
     1  MNGEAICSAL PTIPYHKLAD LRYLSRGASG TVSSARHADW RVQVAVKHLH IHTPLLDSER
    61  KDVLREAEIL HKARFSYILP ILGICNEPEF LGIVTEYMPN GSLNELLHRK TEYPDVAWPL
   121  RFRILHEIAL GVNYLHNMTP PLLHHDLKTQ NILLDNEFHV KIADFGLSKW RMMSLSQSRS
   181  SKSAPEGGTI IYMPPENYEP GQKSRASIKH DIYSYAVITW EVLSRKQPFE DVTNPLQIMY
   241  SVSQGHRPVI NEESLPYDIP HRARMISLIE SGWAQNPDER PSFLKCLIEL EPVLRTFEEI
   301  TFLEAVIQLK KTKLQSVSSA IHLCDKKKME LSLNIPVNHG PQEESCGSSQ LHENSGSPET
   361  SRSLPAPQDN DFLSRKAQDC YFMKLHHCPG NHSWDSTISG SQRAAFCDHK TTPCSSAIIN
   421  PLSTAGNSER LQPGIAQQWI QSKREDIVNQ MTEACLNQSL DALLSRDLIM KEDYELVSTK
   481  PTRTSKVRQL LDTTDIQGEE FAKVIVQKLK DNKQMGLQPY PEILVVSRSP SLNLLQNKSM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RIPK2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
8.8 nTPM

Expression across tissuesHPA

Tissue

  • gallbladder: 8.8 nTPM
  • urinary bladder: 8.8 nTPM
  • bone marrow: 8.4 nTPM
  • tonsil: 6.3 nTPM
  • lymph node: 6.1 nTPM
  • lung: 5.7 nTPM

Single-cell type

  • endometrial glandular cells: 399 nCPM
  • monocytes: 382 nCPM
  • pancreatic duct cells: 303 nCPM
  • monocyte progenitors: 252 nCPM
  • cdc: 242 nCPM
  • megakaryocyte-erythroid progenitors: 242 nCPM

Immune cell

  • eosinophil: 23 nTPM
  • non-classical monocyte: 15 nTPM
  • basophil: 14 nTPM
  • intermediate monocyte: 13 nTPM
  • myeloid DC: 8.1 nTPM
  • memory B-cell: 7.6 nTPM

Brain region

  • white matter: 8.3 nTPM
  • hypothalamus: 7.2 nTPM
  • spinal cord: 6.7 nTPM
  • medulla oblongata: 6.1 nTPM
  • cerebral cortex: 4.6 nTPM
  • hippocampal formation: 4.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.44
gnomAD pLI
0.39
gnomAD missense Z
2.16
DepMap mean gene effect
0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RIPK2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RIPK2 as an antibody target. Whether an autoantibody or antibody against RIPK2 could matter depends on whether native RIPK2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RIPK2 is annotated at the cell surface, where native RIPK2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RIPK2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RIPK2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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