Seroatlas · Human Serome Atlas

HSPB6

Heat shock protein beta-6

Also known as: FLJ32389, Hsp20, HSPB6_HUMAN, PPP1R91

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O14558
Gene: HSPB6
Ensembl: ENSG00000004776
Chromosome: 19
Canonical length: 160 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles,Mitochondria,Cytosol
Secretome location: Intracellular and membrane
Quaternary structure: Homodimer

OverviewNCBI Gene

This locus encodes a heat shock protein. The encoded protein likely plays a role in smooth muscle relaxation. [provided by RefSeq, Jan 2012]

Canonical amino-acid sequenceUniProt

160 residues, UniProt reviewed canonical sequence.

>O14558|HSPB6
     1  MEIPVPVQPS WLRRASAPLP GLSAPGRLFD QRFGEGLLEA ELAALCPTTL APYYLRAPSV
    61  ALPVAQVPTD PGHFSVLLDV KHFSPEEIAV KVVGEHVEVH ARHEERPDEH GFVAREFHRR
   121  YRLPPGVDPA AVTSALSPEG VLSIQAAPAS AQAPPPAAAK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HSPB6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 2,832 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 2,832 nTPM
tongue: 1,642 nTPM
heart muscle: 1,367 nTPM
colon: 668 nTPM
blood vessel: 634 nTPM
adipose tissue: 610 nTPM

Single-cell type

decidual stromal cells: 734 nCPM
thymic myoid cells: 311 nCPM
smooth muscle cells: 265 nCPM
hepatic stellate cells: 265 nCPM
leydig cells: 254 nCPM
vascular smooth muscle cells: 241 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 125 nTPM
pons: 119 nTPM
thalamus: 75 nTPM
spinal cord: 71 nTPM
white matter: 67 nTPM
midbrain: 66 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.35
gnomAD pLI: 0.09
gnomAD missense Z: 1.28
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HSPB6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HSPB6 as an antibody target. Whether an autoantibody or antibody against HSPB6 could matter depends on whether native HSPB6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HSPB6 is annotated as secreted, so native HSPB6 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label HSPB6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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