Seroatlas · Human Serome Atlas

TMEM174

Transmembrane protein 174

Also known as: FLJ31268, MGC13034, TM174_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WUU8
Gene: TMEM174
Ensembl: ENSG00000164325
Chromosome: 5
Canonical length: 243 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to be involved in phosphate ion homeostasis. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

243 residues, UniProt reviewed canonical sequence.

>Q8WUU8|TMEM174
     1  MEQGSGRLED FPVNVFSVTP YTPSTADIQV SDDDKAGATL LFSGIFLGLV GITFTVMGWI
    61  KYQGVSHFEW TQLLGPVLLS VGVTFILIAV CKFKMLSCQL CKESEERVPD SEQTPGGPSF
   121  VFTGINQPIT FHGATVVQYI PPPYGSPEPM GINTSYLQSV VSPCGLITSG GAAAAMSSPP
   181  QYYTIYPQDN SAFVVDEGCL SFTDGGNHRP NPDVDQLEET QLEEEACACF SPPPYEEIYS
   241  LPR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM174 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 143 nTPM

Expression across tissuesHPA

Tissue

kidney: 143 nTPM
cerebral cortex: 0.1 nTPM
thyroid gland: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM

Single-cell type

proximal tubule cells: 11 nCPM
loop of henle epithelial cells: 0.7 nCPM
renal connecting tubule cells: 0.7 nCPM
renal collecting duct intercalated cells: 0.6 nCPM
distal convoluted tubule cells: 0.4 nCPM
epididymal principal cells: 0.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 1 nTPM
medulla oblongata: 0.7 nTPM
spinal cord: 0.6 nTPM
midbrain: 0.4 nTPM
thalamus: 0.2 nTPM
amygdala: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.98
gnomAD pLI: 0.18
gnomAD missense Z: -0.12
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

phosphate ion homeostasis

Cellular components

Protein domainsUniProt · Pfam · InterPro

Transmembrane protein 174
Transmembrane protein 174

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM174 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM174 as an antibody target. Whether an autoantibody or antibody against TMEM174 could matter depends on whether native TMEM174 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM174 is annotated at the cell surface, where native TMEM174 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMEM174 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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