Seroatlas · Human Serome Atlas

MLF2

Myeloid leukemia factor 2

Also known as: MLF2_HUMAN, NTN4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15773
Gene: MLF2
Ensembl: ENSG00000089693
Chromosome: 12
Canonical length: 248 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to be involved in regulation of DNA-templated transcription. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

248 residues, UniProt reviewed canonical sequence.

>Q15773|MLF2
     1  MFRFMRDVEP EDPMFLMDPF AIHRQHMSRM LSGGFGYSPF LSITDGNMPG TRPASRRMQQ
    61  AGAVSPFGML GMSGGFMDMF GMMNDMIGNM EHMTAGGNCQ TFSSSTVISY SNTGDGAPKV
   121  YQETSEMRSA PGGIRETRRT VRDSDSGLEQ MSIGHHIRDR AHILQRSRNH RTGDQEERQD
   181  YINLDESEAA AFDDEWRRET SRFRQQRPLE FRRLESSGAG GRRAEGPPRL AIQGPEDSPS
   241  RQSRRYDW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MLF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 291 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 291 nTPM
liver: 283 nTPM
basal ganglia: 279 nTPM
choroid plexus: 252 nTPM
hippocampal formation: 243 nTPM
amygdala: 240 nTPM

Single-cell type

syncytiotrophoblasts: 489 nCPM
esophageal apical cells: 378 nCPM
esophageal suprabasal cells: 322 nCPM
cytotrophoblasts: 313 nCPM
migrating cytotrophoblasts: 309 nCPM
esophageal basal cells: 302 nCPM

Immune cell

neutrophil: 530 nTPM
eosinophil: 462 nTPM
basophil: 260 nTPM
plasmacytoid DC: 232 nTPM
myeloid DC: 134 nTPM
non-classical monocyte: 130 nTPM

Brain region

cerebral cortex: 230 nTPM
hippocampal formation: 203 nTPM
basal ganglia: 197 nTPM
white matter: 190 nTPM
hypothalamus: 189 nTPM
choroid plexus: 180 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.41
gnomAD pLI: 0.86
gnomAD missense Z: 1.61
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of DNA-templated transcription

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MLF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MLF2 as an antibody target. Whether an autoantibody or antibody against MLF2 could matter depends on whether native MLF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MLF2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MLF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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