Seroatlas · Human Serome Atlas

HSPB2

Heat shock protein beta-2

Also known as: Hs.78846, HSPB2_HUMAN, MKBP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q16082
Gene: HSPB2
Ensembl: ENSG00000170276
Chromosome: 11
Canonical length: 182 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The protein is expressed preferentially in the heart and skeletal muscle. This protein regulates Myotonic Dystrophy Protein Kinase, which plays an important role in maintenance of muscle structure and function. [provided by RefSeq, Dec 2012]

Canonical amino-acid sequenceUniProt

182 residues, UniProt reviewed canonical sequence.

>Q16082|HSPB2
     1  MSGRSVPHAH PATAEYEFAN PSRLGEQRFG EGLLPEEILT PTLYHGYYVR PRAAPAGEGS
    61  RAGASELRLS EGKFQAFLDV SHFTPDEVTV RTVDNLLEVS ARHPQRLDRH GFVSREFCRT
   121  YVLPADVDPW RVRAALSHDG ILNLEAPRGG RHLDTEVNEV YISLLPAPPD PEEEEEAAIV
   181  EP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HSPB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 296 nTPM

Expression across tissuesHPA

Tissue

tongue: 296 nTPM
skeletal muscle: 236 nTPM
heart muscle: 219 nTPM
blood vessel: 101 nTPM
adipose tissue: 76 nTPM
fallopian tube: 49 nTPM

Single-cell type

hepatic stellate cells: 6.5 nCPM
bergmann glia: 6.1 nCPM
astrocytes: 5.4 nCPM
brain excitatory neurons: 4.7 nCPM
oligodendrocytes: 4.3 nCPM
ependymal cells: 1.7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 39 nTPM
medulla oblongata: 22 nTPM
thalamus: 22 nTPM
basal ganglia: 21 nTPM
midbrain: 19 nTPM
spinal cord: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.48
gnomAD pLI: 0
gnomAD missense Z: 0.52
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HSPB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HSPB2 as an antibody target. Whether an autoantibody or antibody against HSPB2 could matter depends on whether native HSPB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HSPB2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HSPB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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