Seroatlas · Human Serome Atlas

BCCIP

BRCA2 and CDKN1A-interacting protein

Also known as: BCCIP_HUMAN, BCCIPalpha, TOK-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P287
Gene: BCCIP
Ensembl: ENSG00000107949
Chromosome: 10
Canonical length: 314 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

314 residues, UniProt reviewed canonical sequence.

>Q9P287|BCCIP
     1  MASRSKRRAV ESGVPQPPDP PVQRDEEEEK EVENEDEDDD DSDKEKDEED EVIDEEVNIE
    61  FEAYSLSDND YDGIKKLLQQ LFLKAPVNTA ELTDLLIQQN HIGSVIKQTD VSEDSNDDMD
   121  EDEVFGFISL LNLTERKGTQ CVEQIQELVL RFCEKNCEKS MVEQLDKFLN DTTKPVGLLL
   181  SERFINVPPQ IALPMYQQLQ KELAGAHRTN KPCGKCYFYL LISKTFVEAG KNNSKKKPSN
   241  KKKAALMFAN AEEEFFYEKA ILKFNYSVQE ESDTCLGGKW SFDDVPMTPL RTVMLIPGDK
   301  MNEIMDKLKE YLSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BCCIP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 74 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 74 nTPM
liver: 64 nTPM
tongue: 60 nTPM
bone marrow: 59 nTPM
salivary gland: 55 nTPM
urinary bladder: 52 nTPM

Single-cell type

differentiating spermatogonia: 166 nCPM
early primary spermatocytes: 149 nCPM
erythrocyte progenitors: 138 nCPM
cardiomyocytes: 119 nCPM
oocytes: 115 nCPM
undifferentiated spermatogonia: 115 nCPM

Immune cell

non-classical monocyte: 95 nTPM
intermediate monocyte: 87 nTPM
MAIT T-cell: 78 nTPM
memory B-cell: 77 nTPM
T-reg: 76 nTPM
myeloid DC: 75 nTPM

Brain region

choroid plexus: 34 nTPM
cerebellum: 31 nTPM
white matter: 30 nTPM
thalamus: 27 nTPM
cerebral cortex: 27 nTPM
medulla oblongata: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.78
gnomAD pLI: 0.01
gnomAD missense Z: -0.1
DepMap mean gene effect: -0.57
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

BCP1 family
BCCIP

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BCCIP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BCCIP as an antibody target. Whether an autoantibody or antibody against BCCIP could matter depends on whether native BCCIP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BCCIP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BCCIP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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