Seroatlas · Human Serome Atlas

DCTN5

Dynactin subunit 5

Also known as: DCTN5_HUMAN, MGC3248, p25

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BTE1
Gene: DCTN5
Ensembl: ENSG00000166847
Chromosome: 16
Canonical length: 182 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear membrane

OverviewNCBI Gene

This gene encodes a subunit of dynactin, a component of the cytoplasmic dynein motor machinery involved in minus-end-directed transport. The encoded protein is a component of the pointed-end subcomplex and is thought to bind membranous cargo. A pseudogene of this gene is located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

182 residues, UniProt reviewed canonical sequence.

>Q9BTE1|DCTN5
     1  MELGELLYNK SEYIETASGN KVSRQSVLCG SQNIVLNGKT IVMNDCIIRG DLANVRVGRH
    61  CVVKSRSVIR PPFKKFSKGV AFFPLHIGDH VFIEEDCVVN AAQIGSYVHV GKNCVIGRRC
   121  VLKDCCKILD NTVLPPETVV PPFTVFSGCP GLFSGELPEC TQELMIDVTK SYYQKFLPLT
   181  QV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DCTN5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 39 nTPM
tonsil: 30 nTPM
esophagus: 24 nTPM
rectum: 23 nTPM
cerebral cortex: 21 nTPM
small intestine: 21 nTPM

Single-cell type

esophageal apical cells: 131 nCPM
late primary spermatocytes: 65 nCPM
early primary spermatocytes: 61 nCPM
neutrophil progenitors: 58 nCPM
esophageal suprabasal cells: 55 nCPM
syncytiotrophoblasts: 55 nCPM

Immune cell

NK-cell: 22 nTPM
non-classical monocyte: 22 nTPM
eosinophil: 20 nTPM
T-reg: 19 nTPM
myeloid DC: 18 nTPM
MAIT T-cell: 17 nTPM

Brain region

cerebral cortex: 57 nTPM
basal ganglia: 57 nTPM
hippocampal formation: 54 nTPM
midbrain: 50 nTPM
hypothalamus: 48 nTPM
amygdala: 48 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0.01
gnomAD missense Z: 1.69
DepMap mean gene effect: -1.22
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Trimeric LpxA-like superfamily
Dynactin subunit 5
Dynactin subunit 5

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DCTN5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DCTN5 as an antibody target. Whether an autoantibody or antibody against DCTN5 could matter depends on whether native DCTN5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DCTN5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DCTN5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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