Rab GTPase-activating TBC domain-containing protein
IPR050302
Definition
This family of proteins includes GTPase-activating proteins (GAPs) that regulate the activity of Rab GTPases, which are key regulators of intracellular membrane trafficking. Members of this family are involved in various cellular processes such as autophagosome formation, cell cycle progression, cytokinesis, endocytosis, and vesicular transport. They function by accelerating the hydrolysis of GTP bound to Rab proteins, converting them from an active GTP-bound state to an inactive GDP-bound state. This action is critical for the control of vesicle budding, transport, and fusion events within the cell. The proteins typically contain TBC domains and may interact with specific Rab GTPases, influencing processes like microtubule nucleation, glucose uptake, and cell migration.
29 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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