Seroatlas · Human Serome Atlas

TBC1D3B

TBC1 domain family member 3B

Also known as: PRC17, TBC1D3I, TBC3B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NDS4
Gene: TBC1D3B
Ensembl: ENSG00000274808
Chromosome: 17
Canonical length: 549 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

This gene encodes a protein that is similar to TBC1 domain family, member 3. This protein contains a TBC (Tre-2, Bub2p, and Cdc16p) domain, which is found in proteins involved in RAB GTPase signaling and vesicle trafficking. There are multiple copies of this gene located within a cluster of chemokine genes on chromosome 17q. [provided by RefSeq, Apr 2009]

Canonical amino-acid sequenceUniProt

549 residues, UniProt reviewed canonical sequence.

>A6NDS4|TBC1D3B
     1  MDVVEVAGSW WAQEREDIIM KYEKGHRAGL PEDKGPKPFR SYNNNVDHLG IVHETELPPL
    61  TAREAKQIRR EISRKSKWVD MLGDWEKYKS SRKLIDRAYK GMPMNIRGPM WSVLLNIEEM
   121  KLKNPGRYQI MKEKGKRSSE HIQRIDRDIS GTLRKHMFFR DRYGTKQREL LHILLAYEEY
   181  NPEVGYCRDL SHIAALFLLY LPEEDAFWAL VQLLASERHS LQGFHSPNGG TVQGLQDQQE
   241  HVVATSQSKT MGHQDKKDLC GQCSPLGCLI RILIDGISLG LTLRLWDVYL VEGEQALMPI
   301  TRIAFKVQQK RLTKTSRCGP WARFCNRFVD TWARDEDTVL KHLRASMKKL TRKQGDLPPP
   361  AKPEQGSSAS RPVPASRGRK TLCKGDRQAP PGPPARFPRP IWSASPPRAP RSSTPCPGGA
   421  VREDTYPVGT QGVPSPALAQ GGPQGSWRFL QWNSMPRLPT DLDVEGPWFR HYDFRQSCWV
   481  RAISQEDQLA PCWQAEHPAE RVRSAFAAPS TDSDQGTPFR ARDEQQCAPT SGPCLCGLHL
   541  ESSQFPPGF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TBC1D3B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

testis: 13 nTPM
cerebellum: 12 nTPM
skin: 5.7 nTPM
esophagus: 5.4 nTPM
cervix: 4.9 nTPM
prostate: 4.9 nTPM

Single-cell type

early spermatids: 15 nCPM
late primary spermatocytes: 2.5 nCPM
proximal tubule cells: 1.3 nCPM
late spermatids: 1.1 nCPM
papillary tip epithelial cells: 1.1 nCPM
podocytes: 1 nCPM

Immune cell

NK-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

pons: 14 nTPM
amygdala: 13 nTPM
cerebral cortex: 11 nTPM
cerebellum: 11 nTPM
thalamus: 11 nTPM
medulla oblongata: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.46
gnomAD pLI: 0.22
gnomAD missense Z: -0.03

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

GTPase activator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TBC1D3B as an antibody target. Whether an autoantibody or antibody against TBC1D3B could matter depends on whether native TBC1D3B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TBC1D3B is annotated at the cell surface, where native TBC1D3B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TBC1D3B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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