Seroatlas · Human Serome Atlas

TBC1D10A

TBC1 domain family member 10A

Also known as: AC004997.C22.2, EPI64, TB10A_HUMAN, TBC1D10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BXI6
Gene: TBC1D10A
Ensembl: ENSG00000099992
Chromosome: 22
Canonical length: 508 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

Enables PDZ domain binding activity. Involved in positive regulation of proteolysis and retrograde transport, endosome to Golgi. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

508 residues, UniProt reviewed canonical sequence.

>Q9BXI6|TBC1D10A
     1  MAKSNGENGP RAPAAGESLS GTRESLAQGP DAATTDELSS LGSDSEANGF AERRIDKFGF
    61  IVGSQGAEGA LEEVPLEVLR QRESKWLDML NNWDKWMAKK HKKIRLRCQK GIPPSLRGRA
   121  WQYLSGGKVK LQQNPGKFDE LDMSPGDPKW LDVIERDLHR QFPFHEMFVS RGGHGQQDLF
   181  RVLKAYTLYR PEEGYCQAQA PIAAVLLMHM PAEQAFWCLV QICEKYLPGY YSEKLEAIQL
   241  DGEILFSLLQ KVSPVAHKHL SRQKIDPLLY MTEWFMCAFS RTLPWSSVLR VWDMFFCEGV
   301  KIIFRVGLVL LKHALGSPEK VKACQGQYET IERLRSLSPK IMQEAFLVQE VVELPVTERQ
   361  IEREHLIQLR RWQETRGELQ CRSPPRLHGA KAILDAEPGP RPALQPSPSI RLPLDAPLPG
   421  SKAKPKPPKQ AQKEQRKQMK GRGQLEKPPA PNQAMVVAAA GDACPPQHVP PKDSAPKDSA
   481  PQDLAPQVSA HHRSQESLTS QESEDTYL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TBC1D10A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 46 nTPM

Expression across tissuesHPA

Tissue

skin: 46 nTPM
esophagus: 45 nTPM
vagina: 41 nTPM
cervix: 33 nTPM
blood vessel: 31 nTPM
spleen: 25 nTPM

Single-cell type

pituicytes/fscs: 83 nCPM
rod photoreceptor cells: 82 nCPM
cone photoreceptor cells: 56 nCPM
proximal tubule cells: 55 nCPM
suprabasal keratinocytes: 40 nCPM
astrocytes: 39 nCPM

Immune cell

non-classical monocyte: 46 nTPM
naive CD4 T-cell: 41 nTPM
eosinophil: 38 nTPM
plasmacytoid DC: 38 nTPM
basophil: 38 nTPM
naive CD8 T-cell: 34 nTPM

Brain region

hypothalamus: 17 nTPM
choroid plexus: 16 nTPM
basal ganglia: 14 nTPM
midbrain: 13 nTPM
thalamus: 13 nTPM
hippocampal formation: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.59
gnomAD pLI: 0
gnomAD missense Z: 1.25
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TBC1D10A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

NHERF1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TBC1D10A as an antibody target. Whether an autoantibody or antibody against TBC1D10A could matter depends on whether native TBC1D10A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TBC1D10A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TBC1D10A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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