Seroatlas · Human Serome Atlas

TBC1D10B

TBC1 domain family member 10B

Also known as: DKFZP434P1750, EPI64B, FLJ13130, Rab27A-GAPbeta, TB10B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q4KMP7
Gene
TBC1D10B
Ensembl
ENSG00000169221
Chromosome
16
Canonical length
808 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Small G proteins of the RAB family (see MIM 179508) function in intracellular vesicle trafficking by switching from the GTP-bound state to the GDP-bound state with the assistance of guanine nucleotide exchange factors (GEFs; see MIM 609700) and GTPase-activating proteins (GAPs). TBC1D10B functions as a GAP for several proteins of the Rab family (Ishibashi et al., 2009 [PubMed 19077034]).[supplied by OMIM, Nov 2010]

Canonical amino-acid sequenceUniProt

808 residues, UniProt reviewed canonical sequence.

>Q4KMP7|TBC1D10B
     1  METGTAPLVA PPRRHGAPAA PSPPPRGSRA GPVVVVAPGP PVTTATSAPV TLVAPGEARP
    61  AWVPGSAETS APAPAPAPAP APAVTGSTVV VLTLEASPEA PKPQLPSGPE SPEPAAVAGV
   121  ETSRALAAGA DSPKTEEARP SPAPGPGTPT GTPTRTPSRT APGALTAKPP LAPKPGTTVA
   181  SGVTARSASG QVTGGHGAAA ATSASAGQAP EDPSGPGTGP SGTCEAPVAV VTVTPAPEPA
   241  ENSQDLGSTS SLGPGISGPR GQAPDTLSYL DSVSLMSGTL ESLADDVSSM GSDSEINGLA
   301  LRKTDKYGFL GGSQYSGSLE SSIPVDVARQ RELKWLDMFS NWDKWLSRRF QKVKLRCRKG
   361  IPSSLRAKAW QYLSNSKELL EQNPGKFEEL ERAPGDPKWL DVIEKDLHRQ FPFHEMFAAR
   421  GGHGQQDLYR ILKAYTIYRP DEGYCQAQAP VAAVLLMHMP AEQAFWCLVQ ICDKYLPGYY
   481  SAGLEAIQLD GEIFFALLRR ASPLAHRHLR RQRIDPVLYM TEWFMCIFAR TLPWASVLRV
   541  WDMFFCEGVK IIFRVALVLL RHTLGSVEKL RSCQGMYETM EQLRNLPQQC MQEDFLVHEV
   601  TNLPVTEALI ERENAAQLKK WRETRGELQY RPSRRLHGSR AIHEERRRQQ PPLGPSSSLL
   661  SLPGLKSRGS RAAGGAPSPP PPVRRASAGP APGPVVTAEG LHPSLPSPTG NSTPLGSSKE
   721  TRKQEKERQK QEKERQKQEK EREKERQKQE KEREKQEKER EKQEKERQKQ EKKAQGRKLS
   781  LRRKADGPPG PHDGGDRPSA EARQDAYF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TBC1D10B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • testis: 34 nTPM
  • skeletal muscle: 31 nTPM
  • spinal cord: 25 nTPM
  • cerebellum: 20 nTPM
  • cerebral cortex: 18 nTPM
  • skin: 18 nTPM

Single-cell type

  • late spermatids: 58 nCPM
  • neutrophils: 56 nCPM
  • megakaryocytes: 50 nCPM
  • neutrophil progenitors: 48 nCPM
  • monocyte progenitors: 43 nCPM
  • monocytes: 27 nCPM

Immune cell

  • eosinophil: 1.7 nTPM
  • neutrophil: 1.3 nTPM
  • gdT-cell: 1.2 nTPM
  • memory CD8 T-cell: 1.2 nTPM
  • NK-cell: 1 nTPM
  • total PBMC: 1 nTPM

Brain region

  • white matter: 50 nTPM
  • medulla oblongata: 48 nTPM
  • cerebral cortex: 44 nTPM
  • thalamus: 42 nTPM
  • spinal cord: 41 nTPM
  • basal ganglia: 41 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.21
gnomAD pLI
1
gnomAD missense Z
1.95
DepMap mean gene effect
-0.18
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TBC1D10B as an antibody target. Whether an autoantibody or antibody against TBC1D10B could matter depends on whether native TBC1D10B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TBC1D10B is annotated at the cell surface, where native TBC1D10B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TBC1D10B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TBC1D10B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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