Seroatlas · Human Serome Atlas

TBC1D14

TBC1 domain family member 14

Also known as: KIAA1322, TBC14_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P2M4
Gene: TBC1D14
Ensembl: ENSG00000132405
Chromosome: 4
Canonical length: 693 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Vesicles

OverviewNCBI Gene

Enables protein kinase binding activity. Involved in negative regulation of autophagy; recycling endosome to Golgi transport; and regulation of autophagosome assembly. Located in several cellular components, including Golgi apparatus; autophagosome; and recycling endosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

693 residues, UniProt reviewed canonical sequence.

>Q9P2M4|TBC1D14
     1  MTDGKLSTST NGVAFMGILD GRPGNPLQNL QHVNLKAPRL LSAPEYGPKL KLRALEDRHS
    61  LQSVDSGIPT LEIGNPEPVP CSAVHVRRKQ SDSDLIPERA FQSACALPSC APPAPSSTER
   121  EQSVRKSSTF PRTGYDSVKL YSPTSKALTR SDDVSVCSVS SLGTELSTTL SVSNEDILDL
   181  VVTSSSSAIV TLENDDDPQF TNVTLSSIKE TRGLHQQDCV HEAEEGSKLK ILGPFSNFFA
   241  RNLLARKQSA RLDKHNDLGW KLFGKAPLRE NAQKDSKRIQ KEYEDKAGRP SKPPSPKQNV
   301  RKNLDFEPLS TTALILEDRP ANLPAKPAEE AQKHRQQYEE MVVQAKKREL KEAQRRKKQL
   361  EERCRVEESI GNAVLTWNNE ILPNWETMWC SRKVRDLWWQ GIPPSVRGKV WSLAIGNELN
   421  ITHELFDICL ARAKERWRSL STGGSEVENE DAGFSAADRE ASLELIKLDI SRTFPNLCIF
   481  QQGGPYHDML HSILGAYTCY RPDVGYVQGM SFIAAVLILN LDTADAFIAF SNLLNKPCQM
   541  AFFRVDHGLM LTYFAAFEVF FEENLPKLFA HFKKNNLTPD IYLIDWIFTL YSKSLPLDLA
   601  CRIWDVFCRD GEEFLFRTAL GILKLFEDIL TKMDFIHMAQ FLTRLPEDLP AEELFASIAT
   661  IQMQSRNKKW AQVLTALQKD SREMEKGSPS LRH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TBC1D14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

stomach: 55 nTPM
skeletal muscle: 48 nTPM
skin: 47 nTPM
kidney: 42 nTPM
amygdala: 41 nTPM
basal ganglia: 40 nTPM

Single-cell type

neutrophils: 895 nCPM
renal collecting duct intercalated cells: 872 nCPM
mast cells: 278 nCPM
macrophages: 190 nCPM
proximal tubule cells: 169 nCPM
distal convoluted tubule cells: 143 nCPM

Immune cell

neutrophil: 41 nTPM
classical monocyte: 13 nTPM
MAIT T-cell: 13 nTPM
T-reg: 12 nTPM
plasmacytoid DC: 12 nTPM
total PBMC: 11 nTPM

Brain region

choroid plexus: 78 nTPM
medulla oblongata: 77 nTPM
hypothalamus: 74 nTPM
midbrain: 70 nTPM
spinal cord: 70 nTPM
thalamus: 69 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.46
gnomAD pLI: 0.04
gnomAD missense Z: 1.17
DepMap mean gene effect: 0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TBC1D14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TBC1D14 as an antibody target. Whether an autoantibody or antibody against TBC1D14 could matter depends on whether native TBC1D14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TBC1D14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TBC1D14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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