Seroatlas · Human Serome Atlas

TBC1D3L

TBC1 domain family member 3L

Also known as: TBC3L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: B9A6J9
Gene: TBC1D3L
Ensembl: ENSG00000274512
Chromosome: 17
Canonical length: 549 aa
Protein class: Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to enable GTPase activator activity. Predicted to be located in early endosome membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

549 residues, UniProt reviewed canonical sequence.

>B9A6J9|TBC1D3L
     1  MDVVEVAGSW WAQEREDIIM KYEKGHRAGL PEDKGPKPFR SYNNNVDHLG IVHETELPPL
    61  TAREAKQIRR EISRKSKWVD MLGDWEKYKS SRKLIDRAYK GMPMNIRGPM WSVLLNTEEM
   121  KLKNPGRYQI MKEKGKRSSE HIQRIDRDVS GTLRKHIFFR DRYGTKQREL LHILLAYEEY
   181  NPEVGYCRDL SHIAALFLLY LPEEDAFWAL VQLLASERHS LQGFHSPNGG TVQGLQDQQE
   241  HVVATSQPKT MGHQDKKDLC GQCSPLGCLI RILIDGISLG LTLRLWDVYL VEGEQALMPI
   301  TRIAFKVQQK RLTKTSRCGP WARFCNRFVD TWARDEDTVL KHLRASMKKL TRKQGDLQPP
   361  AKPEQGSSAS RPVPASRGGK TLCKGDRQAP PGPPARFPRP IWSASPPRAP RSSTPCPGGA
   421  VREDTYPVGT QGVPSPALAQ GGPQGSWRFL QWNSMPRLPT DLDVEGPWFR HYDFRQSCWV
   481  RAISQEDQLA PCWQAEHPAE RVRSAFAAPS TDSDQGTPFR ARDEQPCAPT SGPCLCGLHL
   541  ESSQFPPGF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TBC1D3L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 57 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 57 nTPM
retina: 44 nTPM
skin: 35 nTPM
esophagus: 34 nTPM
prostate: 31 nTPM
liver: 30 nTPM

Single-cell type

papillary tip epithelial cells: 1.3 nCPM
proximal tubule cells: 0.8 nCPM
renal collecting duct intercalated cells: 0.8 nCPM
distal convoluted tubule cells: 0.7 nCPM
renal connecting tubule cells: 0.7 nCPM
loop of henle epithelial cells: 0.6 nCPM

Immune cell

neutrophil: 1 nTPM
classical monocyte: 0.2 nTPM
eosinophil: 0.2 nTPM
memory CD8 T-cell: 0.2 nTPM
naive CD8 T-cell: 0.2 nTPM
NK-cell: 0.2 nTPM

Brain region

cerebellum: 29 nTPM
cerebral cortex: 25 nTPM
amygdala: 22 nTPM
hippocampal formation: 22 nTPM
choroid plexus: 22 nTPM
hypothalamus: 21 nTPM

OntologyGO

Molecular functions

GTPase activator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TBC1D3L as an antibody target. Whether an autoantibody or antibody against TBC1D3L could matter depends on whether native TBC1D3L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TBC1D3L is annotated at the cell surface, where native TBC1D3L is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TBC1D3L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...