Seroatlas · Human Serome Atlas

TBC1D3F

TBC1 domain family member 3F

Also known as: TBC3F_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NER0
Gene: TBC1D3F
Canonical length: 549 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for TBC1D3F in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

549 residues, UniProt reviewed canonical sequence.

>A6NER0|TBC1D3F
     1  MDVVEVAGSW WAQEREDIIM KYEKGHRAGL PEDKGPKPFR SYNNNVDHLG IVHETELPPL
    61  TAREAKQIRR EISRKSKWVD MLGDWEKYKS SRKLIDRAYK GMPMNIRGPM WSVLLNIEEM
   121  KLKNPGRYQI MKEKGKRSSE HIQRIDRDVS GTLRKHIFFR DRYGTKQREL LHILLAYEEY
   181  NPEVGYCRDL SHIAALFLLY LPEEDAFWAL VQLLASERHS LQGFHSPNGG TVQGLQDQQE
   241  HVVATSQPKT MGHQDKKDLC GQCSPLGCLI RILIDGISLG LTLRLWDVYL VEGEQALMPI
   301  TRIAFKVQQK RLTKTSRCGP WARFCNRFVD TWARDEDTVL KHLRASMKKL TRKKGDVPPP
   361  AKPEQGSSAS RPVPASRGGK TLCKGDRQAP PGPPARFPRP IWSASPPRAP RSSTPCPGGA
   421  VREDTYPVGT QGVPSPALAQ GGPQGSWRFL QWNSMPRLPT DLDVEGPWFR HYDFRQSCWV
   481  RAISQEDQLA PCWQAEHPAE RVRSAFAAPS TDSDQGTPFR ARDEQQCAPT SGPCLCGLHL
   541  ESSQFPPGF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TBC1D3F can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 6.4 nTPM

Expression across tissuesHPA

Tissue

testis: 6.4 nTPM
cerebellum: 0.6 nTPM
fallopian tube: 0.6 nTPM
cervix: 0.4 nTPM
skin: 0.3 nTPM
spleen: 0.3 nTPM

Single-cell type

late primary spermatocytes: 0.1 nCPM
late spermatids: 0.1 nCPM
renal collecting duct intercalated cells: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.95
gnomAD pLI: 0
gnomAD missense Z: -0.06

OntologyGO

Molecular functions

GTPase activator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TBC1D3F as an antibody target. Whether an autoantibody or antibody against TBC1D3F could matter depends on whether native TBC1D3F is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TBC1D3F is annotated at the cell surface, where native TBC1D3F is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TBC1D3F as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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