Seroatlas · Human Serome Atlas

GRTP1

Growth hormone-regulated TBC protein 1

Also known as: FLJ22474, GRTP1_HUMAN, TBC1D6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5TC63
Gene: GRTP1
Ensembl: ENSG00000139835
Chromosome: 13
Canonical length: 336 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable GTPase activator activity. Predicted to be active in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

336 residues, UniProt reviewed canonical sequence.

>Q5TC63|GRTP1
     1  MQPAERSRVP RIDPYGFERP EDFDDAAYEK FFSSYLVTLT RRAIKWSRLL QGGGVPRSRT
    61  VKRYVRKGVP LEHRARVWMV LSGAQAQMDQ NPGYYHQLLQ GERNPRLEDA IRTDLNRTFP
   121  DNVKFRKTTD PCLQRTLYNV LLAYGHHNQG VGYCQGMNFI AGYLILITNN EEESFWLLDA
   181  LVGRILPDYY SPAMLGLKTD QEVLGELVRA KLPAVGALME RLGVLWTLLV SRWFICLFVD
   241  ILPVETVLRI WDCLFNEGSK IIFRVALTLI KQHQELILEA TSVPDICDKF KQITKGSFVM
   301  ECHTFMQKIF SEPGSLSMAT VAKLRESCRA RLLAQG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GRTP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 78 nTPM

Expression across tissuesHPA

Tissue

liver: 78 nTPM
duodenum: 43 nTPM
small intestine: 37 nTPM
skin: 24 nTPM
colon: 23 nTPM
esophagus: 20 nTPM

Single-cell type

enterocytes: 136 nCPM
cone photoreceptor cells: 130 nCPM
rod photoreceptor cells: 120 nCPM
colonocytes: 117 nCPM
paneth cells: 101 nCPM
prostatic hillock cells: 86 nCPM

Immune cell

neutrophil: 2.1 nTPM
basophil: 0.6 nTPM
total PBMC: 0.6 nTPM
naive CD4 T-cell: 0.5 nTPM
non-classical monocyte: 0.5 nTPM
classical monocyte: 0.4 nTPM

Brain region

choroid plexus: 15 nTPM
cerebral cortex: 14 nTPM
cerebellum: 9.8 nTPM
white matter: 8.8 nTPM
medulla oblongata: 8.7 nTPM
spinal cord: 8.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.63
gnomAD pLI: 0
gnomAD missense Z: -0.44
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

GTPase activator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

GTPase activation

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GRTP1 as an antibody target. Whether an autoantibody or antibody against GRTP1 could matter depends on whether native GRTP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GRTP1 is annotated at the cell surface, where native GRTP1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GRTP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...