Seroatlas · Human Serome Atlas

EVI5L

EVI5-like protein

Also known as: EVI5L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96CN4
Gene
EVI5L
Ensembl
ENSG00000142459
Chromosome
19
Canonical length
794 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

Enables GTPase activator activity and small GTPase binding activity. Involved in negative regulation of cilium assembly and positive regulation of GTPase activity. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

794 residues, UniProt reviewed canonical sequence.

>Q96CN4|EVI5L
     1  MASPTLSPDS SSQEALSAPT CSPTSDSENL SPDELELLAK LEEQNRLLEA DSKSMRSMNG
    61  SRRNSGSSLV SSSSASSNLS HLEEDTWILW GRIANEWEEW RRRKEKLLKE LIRKGIPHHF
   121  RAIVWQLLCS ATDMPVKNQY SELLKMSSPC EKLIRRDIAR TYPEHEFFKG QDSLGQEVLF
   181  NVMKAYSLVD REVGYCQGSA FIVGLLLMQM PEEEAFCVFV RLMQEYRLRE LFKPSMAELG
   241  LCIYQFEYML QEQLPDLNTH FRSQSFHTSM YASSWFLTLF LTTFPLPVAT RVFDIFMYEG
   301  LEIVFRVGLA LLQVNQAELM QLDMEGMSQY FQRVIPHQFD SCPDKLVLKA YQVKYNPKKM
   361  KRLEKEYAAM KSKEMEEQIE IKRLRTENRL LKQRIETLEK GQVTRAQEAE ENYVIKRELA
   421  VVRQQCSSAA EDLQKAQSTI RQLQEQQENP RLTEDFVSHL ETELEQSRLR ETETLGALRE
   481  MQDKVLDMEK RNSSLPDENN VAQLQEELKA LKVREGQAVA STRELKLQLQ ELSDTWQAHL
   541  ARGGRWKESP RKLVVGELQD ELMSVRLREA QALAEGRELR QRVVELETQD HIHRNLLNRV
   601  EAERAALQEK LQYLAAQNKG LQTQLSESRR KQAEAECKSK EEVMAVRLRE ADSMAAVAEM
   661  RQRIAELEIQ REEGRIQGQL NHSDSSQYIR ELKDQIEELK AEVRLLKGPP PFEDPLAFDG
   721  LSLARHLDED SLPSSDEELL GVGVGAALQD ALYPLSPRDA RFFRRLERPA KDSEGSSDSD
   781  ADELAAPYSQ GLDN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EVI5L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
41 nTPM

Expression across tissuesHPA

Tissue

  • hippocampal formation: 41 nTPM
  • cerebral cortex: 39 nTPM
  • amygdala: 36 nTPM
  • spinal cord: 33 nTPM
  • midbrain: 33 nTPM
  • testis: 32 nTPM

Single-cell type

  • early primary spermatocytes: 102 nCPM
  • oligodendrocytes: 93 nCPM
  • oligodendrocyte progenitor cells: 86 nCPM
  • retinal amacrine cells: 73 nCPM
  • retinal horizontal cells: 70 nCPM
  • retinal ganglion cells: 54 nCPM

Immune cell

  • non-classical monocyte: 1.2 nTPM
  • naive CD8 T-cell: 0.3 nTPM
  • gdT-cell: 0.2 nTPM
  • intermediate monocyte: 0.2 nTPM
  • MAIT T-cell: 0.2 nTPM
  • naive CD4 T-cell: 0.2 nTPM

Brain region

  • cerebral cortex: 88 nTPM
  • white matter: 86 nTPM
  • medulla oblongata: 76 nTPM
  • thalamus: 72 nTPM
  • pons: 68 nTPM
  • amygdala: 68 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.21
gnomAD pLI
1
gnomAD missense Z
4.23
DepMap mean gene effect
-0.11
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EVI5L as an antibody target. Whether an autoantibody or antibody against EVI5L could matter depends on whether native EVI5L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EVI5L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EVI5L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EVI5L. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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