Seroatlas · Human Serome Atlas

TBC1D3

TBC1 domain family member 3

Also known as: DKFZp434P2235, PRC17, TBC1D3A, TBC3A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IZP1
Gene: TBC1D3
Ensembl: ENSG00000274611
Chromosome: 17
Canonical length: 549 aa
Protein class: Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to enable GTPase activator activity. Predicted to be located in early endosome membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

549 residues, UniProt reviewed canonical sequence.

>Q8IZP1|TBC1D3
     1  MDVVEVAGSW WAQEREDIIM KYEKGHRAGL PEDKGPKPFR SYNNNVDHLG IVHETELPPL
    61  TAREAKQIRR EISRKSKWVD MLGDWEKYKS SRKLIDRAYK GMPMNIRGPM WSVLLNTEEM
   121  KLKNPGRYQI MKEKGKRSSE HIQRIDRDVS GTLRKHIFFR DRYGTKQREL LHILLAYEEY
   181  NPEVGYCRDL SHIAALFLLY LPEEDAFWAL VQLLASERHS LQGFHSPNGG TVQGLQDQQE
   241  HVVATSQPKT MGHQDKKDLC GQCSPLGCLI RILIDGISLG LTLRLWDVYL VEGEQALMPI
   301  TRIAFKVQQK RLTKTSRCGP WARFCNRFVD TWARDEDTVL KHLRASMKKL TRKKGDLPPP
   361  AKPEQGSSAS RPVPASRGGK TLCKGDRQAP PGPPARFPRP IWSASPPRAP RSSTPCPGGA
   421  VREDTYPVGT QGVPSPALAQ GGPQGSWRFL QWNSMPRLPT DLDVEGPWFR HYDFRQSCWV
   481  RAISQEDQLA PCWQAEHPAE RVRSAFAAPS TDSDQGTPFR ARDEQQCAPT SGPCLCGLHL
   541  ESSQFPPGF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TBC1D3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 12 nTPM
testis: 5.3 nTPM
cerebellum: 4.1 nTPM
kidney: 3.7 nTPM
small intestine: 3.5 nTPM
retina: 2.8 nTPM

Single-cell type

epididymal clear cells: 6.1 nCPM
epididymal principal cells: 1.4 nCPM
syncytiotrophoblasts: 1.2 nCPM
cytotrophoblasts: 1 nCPM
retinal amacrine cells: 0.7 nCPM
epididymal basal cells: 0.6 nCPM

Immune cell

neutrophil: 0.4 nTPM
memory CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebral cortex: 5.2 nTPM
pons: 0.9 nTPM
thalamus: 0.9 nTPM
amygdala: 0.7 nTPM
basal ganglia: 0.7 nTPM
hippocampal formation: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.26
gnomAD pLI: 0.53
gnomAD missense Z: 0.49

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

GTPase activator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TBC1D3 as an antibody target. Whether an autoantibody or antibody against TBC1D3 could matter depends on whether native TBC1D3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TBC1D3 is annotated at the cell surface, where native TBC1D3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TBC1D3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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