Seroatlas · Human Serome Atlas

TBC1D1

TBC1 domain family member 1

Also known as: KIAA1108, TBC, TBC1, TBCD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86TI0
Gene
TBC1D1
Ensembl
ENSG00000065882
Chromosome
4
Canonical length
1168 aa
Protein class
Predicted intracellular proteins, Transporters
Subcellular location
Nucleoli

OverviewNCBI Gene

TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2 (USP6; MIM 604334), yeast Bub2, and CDC16 (MIM 603461) (White et al., 2000 [PubMed 10965142]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

1168 residues, UniProt reviewed canonical sequence.

>Q86TI0|TBC1D1
     1  MEPITFTARK HLLSNEVSVD FGLQLVGSLP VHSLTTMPML PWVVAEVRRL SRQSTRKEPV
    61  TKQVRLCVSP SGLRCEPEPG RSQQWDPLIY SSIFECKPQR VHKLIHNSHD PSYFACLIKE
   121  DAVHRQSICY VFKADDQTKV PEIISSIRQA GKIARQEELH CPSEFDDTFS KKFEVLFCGR
   181  VTVAHKKAPP ALIDECIEKF NHVSGSRGSE SPRPNPPHAA PTGSQEPVRR PMRKSFSQPG
   241  LRSLAFRKEL QDGGLRSSGF FSSFEESDIE NHLISGHNIV QPTDIEENRT MLFTIGQSEV
   301  YLISPDTKKI ALEKNFKEIS FCSQGIRHVD HFGFICRESS GGGGFHFVCY VFQCTNEALV
   361  DEIMMTLKQA FTVAAVQQTA KAPAQLCEGC PLQSLHKLCE RIEGMNSSKT KLELQKHLTT
   421  LTNQEQATIF EEVQKLRPRN EQRENELIIS FLRCLYEEKQ KEHIHIGEMK QTSQMAAENI
   481  GSELPPSATR FRLDMLKNKA KRSLTESLES ILSRGNKARG LQEHSISVDL DSSLSSTLSN
   541  TSKEPSVCEK EALPISESSF KLLGSSEDLS SDSESHLPEE PAPLSPQQAF RRRANTLSHF
   601  PIECQEPPQP ARGSPGVSQR KLMRYHSVST ETPHERKDFE SKANHLGDSG GTPVKTRRHS
   661  WRQQIFLRVA TPQKACDSSS RYEDYSELGE LPPRSPLEPV CEDGPFGPPP EEKKRTSREL
   721  RELWQKAILQ QILLLRMEKE NQKLQASEND LLNKRLKLDY EEITPCLKEV TTVWEKMLST
   781  PGRSKIKFDM EKMHSAVGQG VPRHHRGEIW KFLAEQFHLK HQFPSKQQPK DVPYKELLKQ
   841  LTSQQHAILI DLGRTFPTHP YFSAQLGAGQ LSLYNILKAY SLLDQEVGYC QGLSFVAGIL
   901  LLHMSEEEAF KMLKFLMFDM GLRKQYRPDM IILQIQMYQL SRLLHDYHRD LYNHLEEHEI
   961  GPSLYAAPWF LTMFASQFPL GFVARVFDMI FLQGTEVIFK VALSLLGSHK PLILQHENLE
  1021  TIVDFIKSTL PNLGLVQMEK TINQVFEMDI AKQLQAYEVE YHVLQEELID SSPLSDNQRM
  1081  DKLEKTNSSL RKQNLDLLEQ LQVANGRIQS LEATIEKLLS SESKLKQAML TLELERSALL
  1141  QTVEELRRRS AEPSDREPEC TQPEPTGD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TBC1D1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
137 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 137 nTPM
  • parathyroid gland: 123 nTPM
  • endometrium: 117 nTPM
  • colon: 101 nTPM
  • skeletal muscle: 99 nTPM
  • smooth muscle: 86 nTPM

Single-cell type

  • neutrophils: 996 nCPM
  • renal collecting duct intercalated cells: 835 nCPM
  • vascular smooth muscle cells: 621 nCPM
  • salivary ionocytes: 465 nCPM
  • podocytes: 426 nCPM
  • renal connecting tubule cells: 421 nCPM

Immune cell

  • non-classical monocyte: 22 nTPM
  • eosinophil: 20 nTPM
  • intermediate monocyte: 18 nTPM
  • neutrophil: 17 nTPM
  • NK-cell: 8.7 nTPM
  • naive B-cell: 8.1 nTPM

Brain region

  • choroid plexus: 126 nTPM
  • hippocampal formation: 91 nTPM
  • amygdala: 80 nTPM
  • cerebral cortex: 76 nTPM
  • basal ganglia: 75 nTPM
  • medulla oblongata: 75 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.7
gnomAD pLI
0
gnomAD missense Z
0.75
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TBC1D1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TBC1D1 as an antibody target. Whether an autoantibody or antibody against TBC1D1 could matter depends on whether native TBC1D1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TBC1D1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TBC1D1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TBC1D1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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