Seroatlas · Human Serome Atlas

TBC1D26

TBC1 domain family member 26

Also known as: TBC26_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86UD7
Gene
TBC1D26
Canonical length
250 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for TBC1D26 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

250 residues, UniProt reviewed canonical sequence.

>Q86UD7|TBC1D26
     1  MEMDGDPYNL PAQGQGNIII TKYEQGHRAG AAVDLGHEQV DVRKYTNNLG IVHEMELPHV
    61  SALEVKQRRK ESKRTNKWQK MLADWTKYRS TKKLSQRVYK VIPLAVRGRA WSLLLDIDRI
   121  KSQNPGKYKV MKEKGKRSSR IIHCIQLDVS HTLQKHMMFI QRFGVKQQEL CDILVAYSAY
   181  NPEVGYHRDL SRITAILLLC LPEEDAFWAL TQLLAGERHS LWYSTAQILP GSRGSYRTRS
   241  RCCTSPSQRS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TBC1D26 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
16 nTPM

Expression across tissuesHPA

Tissue

  • testis: 16 nTPM
  • basal ganglia: 3.1 nTPM
  • hippocampal formation: 2.7 nTPM
  • amygdala: 1.6 nTPM
  • cerebral cortex: 1 nTPM
  • hypothalamus: 0.3 nTPM

Single-cell type

  • brain inhibitory neurons: 8.1 nCPM
  • brain excitatory neurons: 6.6 nCPM
  • early spermatids: 2.3 nCPM
  • late primary spermatocytes: 1.5 nCPM
  • oligodendrocytes: 1.1 nCPM
  • other brain neurons: 1.1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hippocampal formation: 1.3 nTPM
  • basal ganglia: 1.1 nTPM
  • amygdala: 1 nTPM
  • cerebral cortex: 0.7 nTPM
  • medulla oblongata: 0.5 nTPM
  • pons: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.09
gnomAD pLI
0
gnomAD missense Z
0.06
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TBC1D26 as an antibody target. Whether an autoantibody or antibody against TBC1D26 could matter depends on whether native TBC1D26 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TBC1D26 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TBC1D26 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TBC1D26. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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