Seroatlas · Human Serome Atlas

TBC1D28

TBC1 domain family member 28

Also known as: FLJ40244, TBC28_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q2M2D7
Gene
TBC1D28
Ensembl
ENSG00000189375
Chromosome
17
Canonical length
210 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles

OverviewNCBI Gene

No narrative summary is available for TBC1D28 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

210 residues, UniProt reviewed canonical sequence.

>Q2M2D7|TBC1D28
     1  MEMDEDPDNL PAQGQGNIII TKYEQGHRAG AAVDLGHEQV DVRKYTNNLG IVHEMELPRV
    61  SALEVKQRRK ESKRTNKWQK MLADWTKYRS TKKLSQRVCK VIPLAVRGRA LSLLLDIDKI
   121  KSQNPGKYKV MKEKGKRSSR IIHCIQLDVS HTLQKHMMFI QRFGVKQQEL CDILVAYSAY
   181  NPVSIPGQRY SWYLCPYSQA WVSLGGVATS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TBC1D28 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • testis: 18 nTPM
  • tonsil: 0.3 nTPM
  • choroid plexus: 0.2 nTPM
  • spleen: 0.2 nTPM
  • basal ganglia: 0.1 nTPM
  • cerebellum: 0.1 nTPM

Single-cell type

  • early spermatids: 97 nCPM
  • late primary spermatocytes: 32 nCPM
  • late spermatids: 20 nCPM
  • early primary spermatocytes: 2.3 nCPM
  • sertoli cells: 1.2 nCPM
  • podocytes: 0.5 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hippocampal formation: 1.4 nTPM
  • cerebral cortex: 1.2 nTPM
  • basal ganglia: 1 nTPM
  • cerebellum: 1 nTPM
  • amygdala: 0.7 nTPM
  • white matter: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.81
gnomAD pLI
0
gnomAD missense Z
-0.28
DepMap mean gene effect
-0.34
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TBC1D28 as an antibody target. Whether an autoantibody or antibody against TBC1D28 could matter depends on whether native TBC1D28 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TBC1D28 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TBC1D28 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TBC1D28. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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