Seroatlas · Human Serome Atlas

RABGAP1L

Rab GTPase-activating protein 1-like

Also known as: FLJ38519, HHL, KIAA0471, RBG1L_HUMAN, TBC1D18

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5R372
Gene: RABGAP1L
Ensembl: ENSG00000152061
Chromosome: 1
Canonical length: 815 aa
Protein class: Disease related genes, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Enables GTPase activator activity and small GTPase binding activity. Acts upstream of or within regulation of protein localization. Located in several cellular components, including Golgi apparatus; cilium; and early endosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

815 residues, UniProt reviewed canonical sequence.

>Q5R372|RABGAP1L
     1  MEVRASLQKV SGSSDSVATM NSEEFVLVPQ YADDNSTKHE EKPQLKIVSN GDEQLEKAME
    61  EILRDSEKRP SSLLVDCQSS SEISDHSFGD IPASQTNKPS LQLILDPSNT EISTPRPSSP
   121  GGLPEEDSVL FNKLTYLGCM KVSSPRNEVE ALRAMATMKS SSQYPFPVTL YVPNVPEGSV
   181  RIIDQSSNVE IASFPIYKVL FCARGHDGTT ESNCFAFTES SHGSEEFQIH VFSCEIKEAV
   241  SRILYSFCTA FKRSSRQVSD VKDSVIPTPD SDVFTFSVSL EVKEDDGKGN FSPVPKDRDK
   301  FYFKLKQGIE KKVVITVQQL SNKELAIERC FGMLLSPGRN VKNSDMHLLD MESMGKSYDG
   361  RAYVITGMWN PNAPVFLALN EETPKDKQVY MTVAVDMVVT EVVEPVRFLL ETVVRVYPAN
   421  ERFWYFSRKT FTETFFMRLK QSEGKGHTNA GDAIYEVVSL QRESDKEEPV TPTSGGGPMS
   481  PQDDEAEEES DNELSSGTGD VSKDCPEKIL YSWGELLGKW HSNLGARPKG LSTLVKSGVP
   541  EALRAEVWQL LAGCHDNQAM LDRYRILITK DSAQESVITR DIHRTFPAHD YFKDTGGDGQ
   601  ESLYKICKAY SVYDEDIGYC QGQSFLAAVL LLHMPEEQAF CVLVKIMYDY GLRDLYRNNF
   661  EDLHCKFYQL ERLMQEQLPD LHSHFSDLNL EAHMYASQWF LTLFTAKFPL CMVFHIIDLL
   721  LCEGLNIIFH VALALLKTSK EDLLQADFEG ALKFFRVQLP KRYRAEENAR RLMEQACNIK
   781  VPTKKLKKYE KEYQTMRESQ LQQEDPMDRY KFVYL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RABGAP1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 115 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 115 nTPM
tonsil: 44 nTPM
lymph node: 36 nTPM
testis: 29 nTPM
bone marrow: 28 nTPM
spleen: 24 nTPM

Single-cell type

pdcs: 2,128 nCPM
choroid plexus epithelial cells: 1,941 nCPM
cardiomyocytes: 1,614 nCPM
podocytes: 1,592 nCPM
nk-cells: 1,173 nCPM
retinal pigment epithelial cells: 1,138 nCPM

Immune cell

non-classical monocyte: 179 nTPM
eosinophil: 108 nTPM
neutrophil: 87 nTPM
intermediate monocyte: 85 nTPM
NK-cell: 80 nTPM
plasmacytoid DC: 53 nTPM

Brain region

choroid plexus: 149 nTPM
cerebellum: 143 nTPM
cerebral cortex: 95 nTPM
white matter: 93 nTPM
hypothalamus: 90 nTPM
basal ganglia: 89 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RABGAP1L.

Disease | AllUniProt

Conditions RABGAP1L is implicated in, by any mechanism.

Leukemia, acute myelogenous (AML) MIM:601626

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.51
gnomAD pLI: 0
gnomAD missense Z: 1.12
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RABGAP1L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RABGAP1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RABGAP1L as an antibody target. Whether an autoantibody or antibody against RABGAP1L could matter depends on whether native RABGAP1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RABGAP1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RABGAP1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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