ADF-H/Gelsolin-like domain superfamily

Definition

This superfamily represents an ~150-amino acid ADF-H (actin-depolymerising factor homology) domain found in three phylogenetically distinct classes of eukaryotic actin-binding proteins [[cite:PMID:9693358], [cite:PMID:12207032], [cite:PMID:9047337]]. This domain shares structural similarity with another set of actin binding proteins, villin and gelsolin, and the C-terminal of the Sec23/Sec24 proteins. It consists of a mixed β-sheet structure.

24 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (24 proteins: gene, accession, name)

• AVIL
• CAPG
• CFL1
• CFL2
• COTL1
• DBN1
• DBNL
• DSTN
• FLII
• GMFB
• GMFG
• GSN
• SCIN
• SEC23A
• SEC23B
• SEC24A
• SEC24B
• SEC24C
• SEC24D
• SVIL
• TWF1
• TWF2
• VIL1
• VILL