Seroatlas · Human Serome Atlas

GMFB

Glia maturation factor beta

Also known as: GMF, GMFB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P60983
Gene: GMFB
Ensembl: ENSG00000197045
Chromosome: 14
Canonical length: 142 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

Predicted to enable Arp2/3 complex binding activity. Predicted to be involved in actin filament debranching and negative regulation of Arp2/3 complex-mediated actin nucleation. Predicted to act upstream of or within learning and locomotory behavior. Predicted to be active in cortical actin cytoskeleton. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

142 residues, UniProt reviewed canonical sequence.

>P60983|GMFB
     1  MSESLVVCDV AEDLVEKLRK FRFRKETNNA AIIMKIDKDK RLVVLDEELE GISPDELKDE
    61  LPERQPRFIV YSYKYQHDDG RVSYPLCFIF SSPVGCKPEQ QMMYAGSKNK LVQTAELTKV
   121  FEIRNTEDLT EEWLREKLGF FH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GMFB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 98 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 98 nTPM
midbrain: 64 nTPM
cerebral cortex: 63 nTPM
amygdala: 58 nTPM
hippocampal formation: 56 nTPM
hypothalamus: 49 nTPM

Single-cell type

extravillous trophoblasts: 118 nCPM
esophageal apical cells: 79 nCPM
colonocytes: 65 nCPM
syncytiotrophoblasts: 63 nCPM
migrating cytotrophoblasts: 63 nCPM
schwann cells: 60 nCPM

Immune cell

neutrophil: 16 nTPM
non-classical monocyte: 14 nTPM
intermediate monocyte: 13 nTPM
myeloid DC: 13 nTPM
classical monocyte: 10 nTPM
eosinophil: 9.1 nTPM

Brain region

spinal cord: 121 nTPM
white matter: 119 nTPM
hypothalamus: 103 nTPM
medulla oblongata: 97 nTPM
thalamus: 96 nTPM
basal ganglia: 85 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.06
gnomAD pLI: 0.01
gnomAD missense Z: 1.31
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cortical actin cytoskeleton

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GMFB as an antibody target. Whether an autoantibody or antibody against GMFB could matter depends on whether native GMFB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GMFB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GMFB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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