Seroatlas · Human Serome Atlas

SCIN

Scinderin

Also known as: KIAA1905, SCIN_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y6U3
Gene: SCIN
Ensembl: ENSG00000006747
Chromosome: 7
Canonical length: 715 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

SCIN is a Ca(2+)-dependent actin-severing and -capping protein (Zunino et al., 2001 [PubMed 11568009]).[supplied by OMIM, May 2010]

Canonical amino-acid sequenceUniProt

715 residues, UniProt reviewed canonical sequence.

>Q9Y6U3|SCIN
     1  MARELYHEEF ARAGKQAGLQ VWRIEKLELV PVPQSAHGDF YVGDAYLVLH TAKTSRGFTY
    61  HLHFWLGKEC SQDESTAAAI FTVQMDDYLG GKPVQNRELQ GYESNDFVSY FKGGLKYKAG
   121  GVASGLNHVL TNDLTAKRLL HVKGRRVVRA TEVPLSWDSF NKGDCFIIDL GTEIYQWCGS
   181  SCNKYERLKA NQVATGIRYN ERKGRSELIV VEEGSEPSEL IKVLGEKPEL PDGGDDDDII
   241  ADISNRKMAK LYMVSDASGS MRVTVVAEEN PFSMAMLLSE ECFILDHGAA KQIFVWKGKD
   301  ANPQERKAAM KTAEEFLQQM NYSKNTQIQV LPEGGETPIF KQFFKDWRDK DQSDGFGKVY
   361  VTEKVAQIKQ IPFDASKLHS SPQMAAQHNM VDDGSGKVEI WRVENNGRIQ VDQNSYGEFY
   421  GGDCYIILYT YPRGQIIYTW QGANATRDEL TTSAFLTVQL DRSLGGQAVQ IRVSQGKEPV
   481  HLLSLFKDKP LIIYKNGTSK KGGQAPAPPT RLFQVRRNLA SITRIVEVDV DANSLNSNDV
   541  FVLKLPQNSG YIWVGKGASQ EEEKGAEYVA SVLKCKTLRI QEGEEPEEFW NSLGGKKDYQ
   601  TSPLLETQAE DHPPRLYGCS NKTGRFVIEE IPGEFTQDDL AEDDVMLLDA WEQIFIWIGK
   661  DANEVEKKES LKSAKMYLET DPSGRDKRTP IVIIKQGHEP PTFTGWFLGW DSSKW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCIN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 73 nTPM

Expression across tissuesHPA

Tissue

placenta: 73 nTPM
kidney: 44 nTPM
small intestine: 44 nTPM
duodenum: 25 nTPM
stomach: 19 nTPM
colon: 17 nTPM

Single-cell type

renal collecting duct intercalated cells: 731 nCPM
enterocytes: 554 nCPM
renal connecting tubule cells: 331 nCPM
renal collecting duct principal cells: 322 nCPM
hofbauer cells: 241 nCPM
ocular epithelial cells: 211 nCPM

Immune cell

basophil: 1.3 nTPM
memory B-cell: 1.1 nTPM
neutrophil: 0.7 nTPM
naive B-cell: 0.5 nTPM
NK-cell: 0.5 nTPM
gdT-cell: 0.4 nTPM

Brain region

white matter: 26 nTPM
medulla oblongata: 21 nTPM
pons: 18 nTPM
spinal cord: 16 nTPM
cerebral cortex: 14 nTPM
thalamus: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.66
gnomAD pLI: 0
gnomAD missense Z: -0.77
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SCIN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ACTB

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCIN as an antibody target. Whether an autoantibody or antibody against SCIN could matter depends on whether native SCIN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCIN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SCIN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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