Seroatlas · Human Serome Atlas

TWF1

Twinfilin-1

Also known as: A6, PTK9, TWF1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q12792
Gene: TWF1
Ensembl: ENSG00000151239
Chromosome: 12
Canonical length: 350 aa
Protein class: Disease related genes, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

This gene encodes twinfilin, an actin monomer-binding protein conserved from yeast to mammals. Studies of the mouse counterpart suggest that this protein may be an actin monomer-binding protein, and its localization to cortical G-actin-rich structures may be regulated by the small GTPase RAC1. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

350 residues, UniProt reviewed canonical sequence.

>Q12792|TWF1
     1  MSHQTGIQAS EDVKEIFARA RNGKYRLLKI SIENEQLVIG SYSQPSDSWD KDYDSFVLPL
    61  LEDKQPCYIL FRLDSQNAQG YEWIFIAWSP DHSHVRQKML YAATRATLKK EFGGGHIKDE
   121  VFGTVKEDVS LHGYKKYLLS QSSPAPLTAA EEELRQIKIN EVQTDVGVDT KHQTLQGVAF
   181  PISREAFQAL EKLNNRQLNY VQLEIDIKNE IIILANTTNT ELKDLPKRIP KDSARYHFFL
   241  YKHSHEGDYL ESIVFIYSMP GYTCSIRERM LYSSCKSRLL EIVERQLQMD VIRKIEIDNG
   301  DELTADFLYE EVHPKQHAHK QSFAKPKGPA GKRGIRRLIR GPAETEATTD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TWF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 88 nTPM

Expression across tissuesHPA

Tissue

esophagus: 88 nTPM
urinary bladder: 70 nTPM
seminal vesicle: 69 nTPM
thyroid gland: 68 nTPM
duodenum: 65 nTPM
small intestine: 64 nTPM

Single-cell type

esophageal apical cells: 270 nCPM
fallopian tube ciliated cells: 107 nCPM
esophageal suprabasal cells: 105 nCPM
ocular epithelial cells: 75 nCPM
colonocytes: 71 nCPM
syncytiotrophoblasts: 68 nCPM

Immune cell

NK-cell: 12 nTPM
basophil: 10 nTPM
naive CD8 T-cell: 6.7 nTPM
memory CD8 T-cell: 6.6 nTPM
T-reg: 6.6 nTPM
memory B-cell: 6.1 nTPM

Brain region

white matter: 48 nTPM
medulla oblongata: 41 nTPM
basal ganglia: 40 nTPM
hypothalamus: 40 nTPM
spinal cord: 39 nTPM
midbrain: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.86
gnomAD pLI: 0
gnomAD missense Z: 0.92
DepMap mean gene effect: -0.31
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TWF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TWF1 as an antibody target. Whether an autoantibody or antibody against TWF1 could matter depends on whether native TWF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TWF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TWF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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