Seroatlas · Human Serome Atlas

GMFG

Glia maturation factor gamma

Also known as: GMFG_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60234
Gene: GMFG
Ensembl: ENSG00000130755
Chromosome: 19
Canonical length: 142 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

Predicted to enable Arp2/3 complex binding activity. Predicted to be involved in actin filament debranching and negative regulation of Arp2/3 complex-mediated actin nucleation. Predicted to be located in extracellular region; ficolin-1-rich granule lumen; and secretory granule lumen. Predicted to be active in cortical actin cytoskeleton. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

142 residues, UniProt reviewed canonical sequence.

>O60234|GMFG
     1  MSDSLVVCEV DPELTEKLRK FRFRKETDNA AIIMKVDKDR QMVVLEEEFQ NISPEELKME
    61  LPERQPRFVV YSYKYVHDDG RVSYPLCFIF SSPVGCKPEQ QMMYAGSKNR LVQTAELTKV
   121  FEIRTTDDLT EAWLQEKLSF FR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GMFG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 545 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 545 nTPM
thymus: 429 nTPM
spleen: 364 nTPM
lymph node: 280 nTPM
tonsil: 246 nTPM
appendix: 178 nTPM

Single-cell type

neutrophils: 1,712 nCPM
megakaryocytes: 909 nCPM
hofbauer cells: 742 nCPM
neutrophil progenitors: 534 nCPM
monocytes: 457 nCPM
platelets: 454 nCPM

Immune cell

neutrophil: 5,299 nTPM
basophil: 4,411 nTPM
eosinophil: 3,635 nTPM
total PBMC: 2,622 nTPM
T-reg: 1,846 nTPM
non-classical monocyte: 1,695 nTPM

Brain region

white matter: 25 nTPM
medulla oblongata: 22 nTPM
cerebral cortex: 20 nTPM
pons: 20 nTPM
choroid plexus: 18 nTPM
spinal cord: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.64
gnomAD pLI: 0
gnomAD missense Z: 0.18
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GMFG as an antibody target. Whether an autoantibody or antibody against GMFG could matter depends on whether native GMFG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GMFG is annotated as secreted, so native GMFG circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label GMFG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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