Seroatlas · Human Serome Atlas

SEC23B

Protein transport protein Sec23B

Also known as: CDA-II, CDAII, CDAN2, HEMPAS, SC23B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15437
Gene
SEC23B
Ensembl
ENSG00000101310
Chromosome
20
Canonical length
767 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Endoplasmic reticulum,Vesicles,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The function of this gene product has been implicated in cargo selection and concentration. Multiple alternatively spliced transcript variants have been identified in this gene. [provided by RefSeq, Feb 2010]

Canonical amino-acid sequenceUniProt

767 residues, UniProt reviewed canonical sequence.

>Q15437|SEC23B
     1  MATYLEFIQQ NEERDGVRFS WNVWPSSRLE ATRMVVPLAC LLTPLKERPD LPPVQYEPVL
    61  CSRPTCKAVL NPLCQVDYRA KLWACNFCFQ RNQFPPAYGG ISEVNQPAEL MPQFSTIEYV
   121  IQRGAQSPLI FLYVVDTCLE EDDLQALKES LQMSLSLLPP DALVGLITFG RMVQVHELSC
   181  EGISKSYVFR GTKDLTAKQI QDMLGLTKPA MPMQQARPAQ PQEHPFASSR FLQPVHKIDM
   241  NLTDLLGELQ RDPWPVTQGK RPLRSTGVAL SIAVGLLEGT FPNTGARIML FTGGPPTQGP
   301  GMVVGDELKI PIRSWHDIEK DNARFMKKAT KHYEMLANRT AANGHCIDIY ACALDQTGLL
   361  EMKCCANLTG GYMVMGDSFN TSLFKQTFQR IFTKDFNGDF RMAFGATLDV KTSRELKIAG
   421  AIGPCVSLNV KGPCVSENEL GVGGTSQWKI CGLDPTSTLG IYFEVVNQHN TPIPQGGRGA
   481  IQFVTHYQHS STQRRIRVTT IARNWADVQS QLRHIEAAFD QEAAAVLMAR LGVFRAESEE
   541  GPDVLRWLDR QLIRLCQKFG QYNKEDPTSF RLSDSFSLYP QFMFHLRRSP FLQVFNNSPD
   601  ESSYYRHHFA RQDLTQSLIM IQPILYSYSF HGPPEPVLLD SSSILADRIL LMDTFFQIVI
   661  YLGETIAQWR KAGYQDMPEY ENFKHLLQAP LDDAQEILQA RFPMPRYINT EHGGSQARFL
   721  LSKVNPSQTH NNLYAWGQET GAPILTDDVS LQVFMDHLKK LAVSSAC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SEC23B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
67 nTPM

Expression across tissuesHPA

Tissue

  • salivary gland: 67 nTPM
  • pancreas: 60 nTPM
  • thyroid gland: 56 nTPM
  • choroid plexus: 54 nTPM
  • epididymis: 51 nTPM
  • parathyroid gland: 48 nTPM

Single-cell type

  • neutrophils: 186 nCPM
  • salivary acinar cells: 157 nCPM
  • late primary spermatocytes: 128 nCPM
  • monocyte progenitors: 121 nCPM
  • plasma cells: 121 nCPM
  • pancreatic acinar cells: 113 nCPM

Immune cell

  • basophil: 149 nTPM
  • myeloid DC: 108 nTPM
  • eosinophil: 106 nTPM
  • total PBMC: 104 nTPM
  • intermediate monocyte: 96 nTPM
  • non-classical monocyte: 96 nTPM

Brain region

  • white matter: 78 nTPM
  • choroid plexus: 58 nTPM
  • medulla oblongata: 58 nTPM
  • basal ganglia: 56 nTPM
  • cerebellum: 52 nTPM
  • spinal cord: 52 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SEC23B.

Disease | AllUniProt

Conditions SEC23B is implicated in, by any mechanism.

Disease | GeneticClinVar

99 pathogenic / likely-pathogenic of 819 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Congenital dyserythropoietic anemia, type II
  • Cowden syndrome 7
  • SEC23B-related disorder
  • See cases
  • Non-Fanconi anemia cytopenia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.98
gnomAD pLI
0
gnomAD missense Z
0.47
DepMap mean gene effect
0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SEC23B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SEC23B as an antibody target. Whether an autoantibody or antibody against SEC23B could matter depends on whether native SEC23B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SEC23B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SEC23B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SEC23B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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